FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\OtopLa1
Open Close
General Information
Symbol
Dmel\OtopLa1
Species
D. melanogaster
Name
FlyBase ID
FBal0369062
Feature type
allele
Associated gene
Dmel\OtopLa
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Mi et al., 2021)
Progenitor genotype
Cytology
Description

430bp out-of-frame deletion within the OtopLa coding sequence; deletes sequence encoding the 6th transmembrane segment.

(Mi et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:5,630,257..5,630,686 [-]
Comment:

A 430bp deletion within the OtopLa coding sequence.

(Zhang, 2021.8.17)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      OtopLa1 individuals show an aversive response to low-acid foods (HCl, Citric acid and Malic acid), instead of the preference observed in controls, and a reduced proboscis extension reflex response to low-acid. L6 sensilla fire significantly fewer action potentials in response to acid (low or high concentration) than controls.

      OtopLa1 individuals expressing OtopLaE638A.UAS under the control of Scer\GAL4Gr5a.8.5 show an aversive response to low-acid foods (HCl, Citric acid and Malic acid), instead of the preference observed in controls, and a reduced proboscis extension reflex response to low-acid.

      (Mi et al., 2021)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      OtopLa1 is rescued by Scer\GAL4OtopLa.PM/OtopLaUAS.cMa

      (Mi et al., 2021)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      OtopLa1
      otopla1
      (Mi et al., 2023, Mi et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)