FlyBase Allele Report: Dmel\CRMP[TH02545.N]

General Information

Symbol

Dmel\CRMP^TH02545.N

Species

D. melanogaster

Name

FlyBase ID

FBal0369070

Feature type

allele

Associated gene

Dmel\CRMP

Associated Insertion(s)

Carried in Construct

P{TH02545.N}

Key Links

Transgenic product class

RNAi_reagent

(Zhao et al., 2021)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Zhao et al., 2021)

Mutagen

in vitro construct

(Zhao et al., 2021)

Progenitor genotype

Carried in construct

P{TH02545.N}

Cytology

Description

UAS regulatory sequences drive expression of an shRNA that targets CRMP.

(Zhao et al., 2021)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

CRMP

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates fragile X syndrome

modeled by Fmr1^Δ50M, Fmr1³

(Zhao et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm | adult stage, with Scer\GAL4^elav-C155

(Zhao et al., 2021)

abnormal neuroanatomy | adult stage, with Scer\GAL4^elav-C155

(Zhao et al., 2021)

Phenotype Manifest In

axon terminus | adult stage, with Scer\GAL4^elav-C155

(Zhao et al., 2021)

l-LNv neuron, with Scer\GAL4^elav-C155

(Zhao et al., 2021)

Detailed Description

Statement

Reference

Adults expressing CRMP^TH02545.N under the control of Scer\GAL4^elav-C155 show circadian arrhythmicity. Their lLNvs show a split POT.

(Zhao et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/CRMP^TH02545.N is a suppressor | partially of abnormal circadian rhythm | adult stage phenotype of Fmr1^Δ50M/Fmr1³

(Zhao et al., 2021)

Scer\GAL4^elav-C155/CRMP^TH02545.N is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of Fmr1^Δ50M/Fmr1³

(Zhao et al., 2021)

CRMP^TH02545.N/Scer\GAL4^Ilp2.PR is a suppressor | partially of abnormal circadian rhythm | adult stage phenotype of Fmr1^Δ50M/Fmr1³

(Zhao et al., 2021)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Pdf.PU/CRMP^TH02545.N is a non-suppressor of abnormal circadian rhythm | adult stage phenotype of Fmr1^Δ50M/Fmr1³

(Zhao et al., 2021)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/CRMP^TH02545.N is a suppressor | partially of axon terminus | adult stage phenotype of Fmr1^Δ50M/Fmr1³

(Zhao et al., 2021)

Scer\GAL4^elav-C155/CRMP^TH02545.N is a suppressor | partially of adult s-LNv neuron phenotype of Fmr1^Δ50M/Fmr1³

(Zhao et al., 2021)

Scer\GAL4^elav-C155/CRMP^TH02545.N is a suppressor | partially of l-LNv neuron phenotype of Fmr1^Δ50M/Fmr1³

(Zhao et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CRMP^TH02545.N

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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