Arp53D^KO homo- and heterozygous males produce more adult progeny than 'wild-type' controls. Arp53D^KO homozygous males produce more adult progeny than 'wild-type' controls in competition assays, but show lower fitness than 'wild-type' controls, as controls progressive increase in proportion of population over 20 generations.

Arp53D^KO homozygous females produce fewer adult progeny at 29[o]C, but not at 25[o]C, whether crossed to Arp53D^KO homo-, heterozygous, or 'wild-type' control males, although the phenotype is more severe when crossed to Arp53D^KO homozygotes. According, Arp53D^KO homozygous females produce fewer larvae at 29[o]C, whether crossed to Arp53D^KO homozygous or 'wild-type' males, although the phenotype is more severe when crossed to Arp53D^KO homozygotes.

Embryos from Arp53D^KO homozygous parents exhibit abnormal nuclei that appear disorganized and lack compaction, as well as 'nuclear fallout', as compared to controls. Embryos from Arp53D^KO/Arp53D^WT.KI transheterozygotes also exhibit abnormal nuclei that appear disorganized and lack compaction, as well as 'nuclear fallout', as compared to controls.