FlyBase Allele Report: Dmel\fd96Cb[stop]

General Information

Symbol

Dmel\fd96Cb^stop

Species

D. melanogaster

Name

FlyBase ID

FBal0369438

Feature type

allele

Associated gene

Dmel\fd96Cb

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Ruiz-Losada et al., 2021)

Progenitor genotype

Cytology

Description

9 nucleotide sequence change and 3bp deletion near the beginning of the fd96Cb coding region, resulting in a premature stop codon.

(Ruiz-Losada et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3R:25,095,207..25,095,218 [+]

Comment:

A 9 bp insertion and a 3bp deletion near the beginning of the fd96Cb coding region, resulting in a premature stop codon.

Inserted_sequence:

ATAACTAAC

(Ruiz-Losada et al., 2021)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

fd96Ca^5nt, fd96Cb^stop has short lived phenotype

(Ruiz-Losada et al., 2021)

fd96Ca^5nt, fd96Cb^stop has abnormal locomotor behavior | adult stage phenotype

(Ruiz-Losada et al., 2021)

fd96Ca^5nt, fd96Cb^stop has increased cell death | adult stage phenotype

(Ruiz-Losada et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

fd96Cb^stop/fd96Cb^stop is an enhancer of sex comb tooth | decreased number phenotype of fd96Ca^5nt

(Ruiz-Losada et al., 2021)

NOT Enhancer of

Statement

Reference

fd96Cb^GFP.FPTB, fd96Cb^stop/fd96Cb^stop is a non-enhancer of sex comb tooth | decreased number phenotype of fd96Ca^5nt

(Ruiz-Losada et al., 2021)

NOT Suppressor of

Statement

Reference

fd96Cb^GFP.FPTB, fd96Cb^stop/fd96Cb^stop is a non-suppressor of sex comb tooth | decreased number phenotype of fd96Ca^5nt

(Ruiz-Losada et al., 2021)

Other

Statement

Reference

fd96Ca^5nt, fd96Cb^stop has leg joint phenotype

(Ruiz-Losada et al., 2021)

fd96Ca^5nt, fd96Cb^stop has sex comb tooth | decreased number phenotype

(Ruiz-Losada et al., 2021)

fd96Ca^5nt, fd96Cb^stop has prothoracic metatarsal segment transverse row bristle | decreased number phenotype

(Ruiz-Losada et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

fd96Ca^5nt, fd96Cb^stop double homozygotes reach adulthood but get caught in the food where they die soon afterwards; their legs show defects in the formation of the sex comb (strongly reduced number of sex comb bristles) and some necrotic tissue in a few joints; the pattern of transverse row bristles is slightly altered.

(Ruiz-Losada et al., 2021)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fd5^stop

(Ruiz-Losada et al., 2021)

fd96Cb^stop

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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