FlyBase Allele Report: Dmel\Rab40[indel]

General Information

Symbol

Dmel\Rab40^indel

Species

D. melanogaster

Name

FlyBase ID

FBal0369472

Feature type

allele

Associated gene

Dmel\Rab40

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Duan et al., 2021)

Progenitor genotype

Cytology

Description

A single nucleotide deletion in the coding sequence of Rab40, resulting in a protein in which the majority of wild type Rab40 is replaced with a missense sequence.

(Duan et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:12,461,584..12,461,584 [-]

Comment:

A single nucleotide deletion in the coding sequence of Rab40, resulting in a protein in which the majority of wild type Rab40 is replaced with a missense sequence.

(Duan et al., 2021)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

long lived | female limited

(Duan et al., 2021)

semi-sterile

(Duan et al., 2021)

Phenotype Manifest In

autolysosome | early third instar larval stage

(Duan et al., 2021)

embryonic/larval fat body | early third instar larval stage

(Duan et al., 2021)

lipid droplet | early third instar larval stage

(Duan et al., 2021)

lysosome | decreased number | early third instar larval stage

(Duan et al., 2021)

lysosome | early third instar larval stage

(Duan et al., 2021)

Detailed Description

Statement

Reference

Rab40^indel/Rab40^indel early third instar larval fat bodies display larger lipid droplets, fewer and smaller lysosomes, smaller autolysosomes, and larger medial Golgi.

(Duan et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Rab40^indel/Rab40^indel is a suppressor | partially of embryonic/larval fat body | early third instar larval stage phenotype of Scer\GAL4^Cg.PA, bmm^UAS.Tag:V5

(Duan et al., 2021)

Rab40^indel/Rab40^indel is a suppressor | partially of lipid droplet | early third instar larval stage phenotype of Scer\GAL4^Cg.PA, bmm^UAS.Tag:V5

(Duan et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Rab40^indel is rescued by Rab40^+tgr

(Duan et al., 2021)

Rab40^indel is rescued by Rab40^mCul5gr

(Duan et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Rab40-indel

(Duan et al., 2021)

Rab40^-

(Duan et al., 2021)

Rab40^indel

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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