FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ire1H890A
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General Information
Symbol
Dmel\Ire1H890A
Species
D. melanogaster
Name
FlyBase ID
FBal0369587
Feature type
allele
Associated gene
Dmel\Ire1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Mitra and Ryoo, 2021)
gene targeting by homologous recombination
(Mitra and Ryoo, 2021)
Progenitor genotype
Cytology
Description

Amino acid replacement: H890A.

(Mitra and Ryoo, 2021)

Mutation is in the essential His residue of the RNase domain.

(Mitra and Ryoo, 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
3R:19,854,996..19,854,997 [-]
Nucleotide change:

CA19854997GC

Reported nucleotide change:

CA?GC

Amino acid change:

H890A | Ire1-PB

Reported amino acid change:

H890A

(Mitra and Ryoo, 2021)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ire1H890A
      (Mitra and Ryoo, 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)