FB2026_02 , released June 18, 2026
Allele: Dmel\Top140
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General Information
Symbol
Dmel\Top140
Species
D. melanogaster
Name
FlyBase ID
FBal0369618
Feature type
allele
Associated gene
Dmel\Top1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Huang et al., 2021)
Mutagen
CRISPR/Cas9
(Huang et al., 2021)
Progenitor genotype
Cytology
Description

8bp deletion within the Top1 coding region leads to a frame-shift and premature stop codon downstream.

(Huang et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:15,322,711..15,322,718 [+]
Comment:

An 8bp deletion within the Top1 coding region leads to a frame-shift and early translation termination.

(Rong, 2021.10.30)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Top140
      (Huang et al., 2021, Rong, 2021.10.30)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)