FlyBase Allele Report: Dmel\Hecw[CI]

General Information

Symbol

Dmel\Hecw^CI

Species

D. melanogaster

Name

FlyBase ID

FBal0369945

Feature type

allele

Associated gene

Dmel\Hecw

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Fajner et al., 2021)

Progenitor genotype

Cytology

Description

A catalytically inactive (CI) mutant of Hecw.

(Fajner et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult brain

(Fajner et al., 2021)

egg chamber

(Fajner et al., 2021)

female germline cell

(Fajner et al., 2021)

nurse cell ring canal

(Fajner et al., 2021)

oocyte | ectopic

(Fajner et al., 2021)

Detailed Description

Statement

Reference

Hecw^CI homozygotes display a progressive decrease in climbing ability; the brain of 30- and 60-days old adults show extensive vacuolization. Females show oogenesis defects: egg chambers show altered number of germ cells, with increased or decreased number of nurse cells and ring canals, compound egg chambers and oocyte mis-specification.

(Fajner et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hecw^CI has abnormal cell number | oogenesis phenotype, enhanceable by Fmr1^Δ113M

(Fajner et al., 2021)

Suppressed by

Statement

Reference

Hecw^CI has abnormal cell number | oogenesis phenotype, suppressible | partially by orb^F343/orb[+]

(Fajner et al., 2021)

Enhancer of

Statement

Reference

Hecw^CI/Hecw^CI is an enhancer of abnormal cell number | oogenesis phenotype of Fmr1^Δ113M

(Fajner et al., 2021)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hecw^CI has egg chamber phenotype, enhanceable by Fmr1^Δ113M

(Fajner et al., 2021)

Hecw^CI has female germline cell phenotype, enhanceable by Fmr1^Δ113M

(Fajner et al., 2021)

Suppressed by

Statement

Reference

Hecw^CI has female germline cell phenotype, suppressible | partially by orb^F343/orb[+]

(Fajner et al., 2021)

Hecw^CI has egg chamber phenotype, suppressible | partially by orb^F343/orb[+]

(Fajner et al., 2021)

Hecw^CI has oocyte | ectopic phenotype, suppressible | partially by orb^F343/orb[+]

(Fajner et al., 2021)

Enhancer of

Statement

Reference

Hecw^CI/Hecw^CI is an enhancer of egg chamber phenotype of Fmr1^Δ113M

(Fajner et al., 2021)

Hecw^CI/Hecw^CI is an enhancer of female germline cell phenotype of Fmr1^Δ113M

(Fajner et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

94132

Hecw^CI v¹/FM7a, w^*

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hecw^CI

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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