FB2026_02 , released June 18, 2026
Allele: Dmel\AmnionlessNSI-1
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General Information
Symbol
Dmel\AmnionlessNSI-1
Species
D. melanogaster
Name
FlyBase ID
FBal0371575
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Deletion producing a frameshift followed by a premature stop codon, resulting in expression of a truncated Amnionless protein lacking the FXNPXF domain required for ligand-independent internalisation, but retaining the three-faced β-helix and the transmembrane domains required in vertebrates for docking of cubilin trimers and their traffic to the membrane (384 wild type amino acids, followed by 6 novel amino acids).

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

A 7bp deletion in Amnionless starting in codon L386 that causes a frameshift and leads to early translation termination after the addition of 6 novel amino acids.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

AmnionlessNSI-1 homozygous larval nephrocytes exhibit aberrant distribution of slit diaphragms in internal membranes, as well as acentric nuclei.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
AmnionlessNSI-1
Name Synonyms
Secondary FlyBase IDs
    References (1)