FB2026_02 , released June 18, 2026
Allele: Dmel\p53B41.5
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General Information
Symbol
Dmel\p53B41.5
Species
D. melanogaster
Name
FlyBase ID
FBal0371639
Feature type
allele
Associated gene
Dmel\p53
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Chakravarti et al., 2022)
Progenitor genotype
Cytology
Description

14bp deletion ( 3R:23053726..23053739 , release 6 genome), plus 1bp insertion (A) in the unique second coding exon of the p53 B isoform. This creates a frameshift with a stop codon soon afterwards. This mutant specifically disrupts the B isoform, leaving other isoforms unaffected.

(Chakravarti et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:23,053,726..23,053,739 [-]
Comment:

14bp deletion and 1bp insertion (A) causing a frameshift and early translation termination specifically in the p53-PB isoform.

Inserted_sequence:

A

(Chakravarti et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      p53B41.5 has visible | maternal effect phenotype, enhanceable by okrAA/okrRU

      (Chakravarti et al., 2022)
      Suppressed by
      Statement
      Reference

      p53B41.5 has abnormal DNA repair | oogenesis phenotype, suppressible by mei-W681

      (Chakravarti et al., 2022)
      NOT Suppressor of
      Statement
      Reference

      p53B41.5 is a non-suppressor of female sterile phenotype of okrAA/okrRU

      (Chakravarti et al., 2022)

      p53B41.5 is a non-suppressor of lethal - all die during embryonic stage | maternal effect phenotype of okrAA/okrRU

      (Chakravarti et al., 2022)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      p53B41.5 has egg | maternal effect phenotype, enhanceable by okrAA/okrRU

      (Chakravarti et al., 2022)
      Suppressed by
      Statement
      Reference

      p53B41.5 has ovariole phenotype, suppressible by mei-W681

      (Chakravarti et al., 2022)
      NOT Enhancer of
      Statement
      Reference

      p53B41.5 is a non-enhancer of karyosome phenotype of okrAA/okrRU

      (Chakravarti et al., 2022)
      NOT Suppressor of
      Statement
      Reference

      p53B41.5 is a non-suppressor of karyosome phenotype of okrAA/okrRU

      (Chakravarti et al., 2022)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      p53B41.5
      (Chakravarti et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)