FlyBase Allele Report: Dmel\bumpel[2]

General Information

Symbol

Dmel\bumpel²

Species

D. melanogaster

Name

FlyBase ID

FBal0371682

Feature type

allele

Associated gene

Dmel\bumpel

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Yildirim et al., 2022)

Progenitor genotype

Cytology

Description

2bp deletion plus 9bp insertion within bumpel, resulting in a premature stop codon.

(Yildirim et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3R:11,418,318..11,418,319 [-]

Comment:

A 2bp deletion and a 9bp insertion (unspecified) at position 264 (in codon 88) of @bumpel leading to premature termination of translation after 87 amino acids.

Inserted_sequence:

RNNNNNNNN

(Yildirim et al., 2022)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

bumpel², kumpel² has female sterile phenotype, suppressible by Mmus\Slc5a2^UAS.cYa/Scer\GAL4^Act5C.PI

(Yildirim et al., 2022)

bumpel², kumpel² has female sterile phenotype, suppressible by Scer\GAL4^Act5C.PI/Mmus\Slc5a8^UAS.cYa

(Yildirim et al., 2022)

bumpel², kumpel² has female sterile phenotype, suppressible by Mmus\Slc5a2^UAS.cYa/Scer\GAL4^nrv2.PS

(Yildirim et al., 2022)

bumpel², kumpel² has female sterile phenotype, suppressible by Scer\GAL4^Act5C.PI/kumpel^UAS.PD

(Yildirim et al., 2022)

bumpel², kumpel² has female sterile phenotype, suppressible by Hsap\SLC5A12^UAS.cYa/Scer\GAL4^Act5C.PI

(Yildirim et al., 2022)

bumpel², kumpel² has female sterile phenotype, suppressible by Scer\GAL4^Act5C.PI/Mmus\Slc5a7^UAS.cYa

(Yildirim et al., 2022)

bumpel², kumpel² has female sterile phenotype, suppressible by Scer\GAL4^Act5C.PI/Mmus\Slc5a3^UAS.cYa

(Yildirim et al., 2022)

bumpel², kumpel² has female sterile phenotype, suppressible by Mmus\Slc5a1^UAS.cYa/Scer\GAL4^Act5C.PI

(Yildirim et al., 2022)

bumpel², kumpel² has female sterile phenotype, suppressible by Mmus\Slc5a5^UAS.cYa/Scer\GAL4^Act5C.PI

(Yildirim et al., 2022)

bumpel², kumpel² has female sterile phenotype, suppressible by Scer\GAL4^Act5C.PI/Mmus\Slc5a9^UAS.cYa

(Yildirim et al., 2022)

bumpel², kumpel² has female sterile phenotype, suppressible by Scer\GAL4^Act5C.PI/Rnor\Slc5a10^UAS.cYa

(Yildirim et al., 2022)

bumpel², kumpel² has female sterile phenotype, suppressible by Mmus\Slc5a2^UAS.cYa/Scer\GAL4^repo.PL

(Yildirim et al., 2022)

Other

Statement

Reference

bumpel², kumpel² has viable phenotype

(Yildirim et al., 2022)

bumpel², kumpel² has female sterile phenotype

(Yildirim et al., 2022)

bumpel², kumpel² has decreased fecundity | female phenotype

(Yildirim et al., 2022)

bumpel², bumpel^3.1.Tag:V5, kumpel² has female fertile phenotype

(Yildirim et al., 2022)

bumpel², kumpel², rumpel^Δ+Cherry has viable phenotype

(Yildirim et al., 2022)

bumpel², kumpel², rumpel^Δ+Cherry has female sterile phenotype

(Yildirim et al., 2022)

bumpel², kumpel², rumpel^Δ+Cherry has abnormal locomotor behavior | third instar larval stage phenotype

(Yildirim et al., 2022)

bumpel², kumpel², rumpel^Δ+Cherry has decreased fecundity | female phenotype

(Yildirim et al., 2022)

Mmus\Slc5a2^UAS.cYa, Scer\GAL4^repo.PL, bumpel², kumpel² has lethal - all die before end of larval stage | maternal effect phenotype

(Yildirim et al., 2022)

Phenotype Manifest In

Other

Statement

Reference

bumpel², kumpel², rumpel^Δ+Cherry has unfertilized egg | absent phenotype

(Yildirim et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

In bumpel², kumpel² double homozygous females, oogenesis appears disrupted from stage 8, and no normal eggs are formed, and they cannot be fertilized. In bumpel², kumpel², rumpel^Δ+Cherry triple homozygous females oogenesis is blocked at stage 8. Triple mutant third instar larvae show decreased crawling at elevated temperatures (32[o]C): reduced distance to origin, but faster movement, and altered bending behavior.

(Yildirim et al., 2022)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

bumpel²

bumpel⁴²

(Yildirim et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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