FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SREBPlexA::p65
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General Information
Symbol
Dmel\SREBPlexA::p65
Species
D. melanogaster
Name
FlyBase ID
FBal0373681
Feature type
allele
Associated gene
Dmel\SREBP
Associated Insertion(s)
Carried in Construct
P{lexA-dSREBPg.K}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Charroux and Royet, 2022)
Progenitor genotype
Carried in construct
P{lexA-dSREBPg.K}
Cytology
Description

bHLH domain of SREBP has been replaced by sequence encoding a lexA::p65 driver in the context of a genomic fragment that is expressed under the control of the native SREBP promoter. The protein produced is subject to the same physiologically-regulated proteolytic processing as endogenous SREBP. Thus, this construct acts as a reporter to follow SREBP protein activation in vivo.

(Charroux and Royet, 2022)
Allele components
Component
Use(s)
Regulatory region(s)
SREBP
Encoded product / tool
SREBP
Tagged with
lexA::p65
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SREBPlexA::p65
      Name Synonyms
      Secondary FlyBase IDs
        References (1)