FlyBase Allele Report: Dmel\Fer2[fTRG00336.sfGFP-TVPTBF]

General Information

Symbol

Dmel\Fer2^{fTRG00336.sfGFP-TVPTBF}

Species

D. melanogaster

Name

FlyBase ID

FBal0373863

Feature type

allele

Associated gene

Dmel\Fer2

Associated Insertion(s)

Carried in Construct

PBac{fTRG00336.sfGFP-TVPTBF}

Key Links

Transgenic product class

genomic_DNA

(Sarov et al., 2016)

wild_type

(Sarov et al., 2016)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Sarov et al., 2016)

wild_type

(Sarov et al., 2016)

Mutagen

in vitro construct

(Sarov et al., 2016, Bou Dib et al., 2014)

Progenitor genotype

Carried in construct

PBac{fTRG00336.sfGFP-TVPTBF}

Cytology

Description

Carries a fosmid genomic fragment in which Fer2 has been fused in-frame at its C-terminus to superfolder GFP (and other tags or in vitro protease cleavage motifs).

(Sarov et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

Fer2

Encoded product / tool

Fer2

Tagged with

sfGFP

green fluorescent protein

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 8

modeled by Lrrk^I1915T.UAS

(Miozzo et al., 2022)

modeled by Lrrk^UAS.cIa

(Miozzo et al., 2022)

ameliorates Parkinson's disease 2

modeled by park¹

(Miozzo et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Fer2^{fTRG00336.sfGFP-TVPTBF} is a suppressor | partially of abnormal neuroanatomy | adult stage | progressive phenotype of Lrrk^I1915T.UAS, Scer\GAL4^GMR58E02

(Miozzo et al., 2022)

Fer2^{fTRG00336.sfGFP-TVPTBF} is a suppressor | partially of decreased cell number | adult stage | progressive phenotype of Lrrk^I1915T.UAS, Scer\GAL4^GMR58E02

(Miozzo et al., 2022)

NOT Suppressor of

Statement

Reference

Fer2^{fTRG00336.sfGFP-TVPTBF} is a non-suppressor of abnormal neuroanatomy | adult stage | progressive phenotype of Lrrk^UAS.cIa, Scer\GAL4^GMR58E02

(Miozzo et al., 2022)

Fer2^{fTRG00336.sfGFP-TVPTBF} is a non-suppressor of decreased cell number | adult stage | progressive phenotype of Lrrk^UAS.cIa, Scer\GAL4^GMR58E02

(Miozzo et al., 2022)

Phenotype Manifest In

Suppressor of

Statement

Reference

Fer2^{fTRG00336.sfGFP-TVPTBF} is a suppressor | partially of adult dopaminergic PAM neuron | adult stage | decreased number phenotype of Lrrk^I1915T.UAS, Scer\GAL4^GMR58E02

(Miozzo et al., 2022)

Fer2^{fTRG00336.sfGFP-TVPTBF} is a suppressor of mitochondrion | adult stage phenotype of park¹

(Miozzo et al., 2022)

Fer2^{fTRG00336.sfGFP-TVPTBF} is a suppressor of adult dopaminergic PAM neuron | adult stage phenotype of park¹

(Miozzo et al., 2022)

NOT Suppressor of

Statement

Reference

Fer2^{fTRG00336.sfGFP-TVPTBF} is a non-suppressor of adult dopaminergic PAM neuron | adult stage | decreased number phenotype of Lrrk^UAS.cIa, Scer\GAL4^GMR58E02

(Miozzo et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Fer2^{fTRG00336.sfGFP-TVPTBF} rescues Fer2^e03248

(Miozzo et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v318537

PBac{fTRG00336.sfGFP-TVPTBF}VK00033

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Fer2^EGFP

Fer2^{T:Avic\GFP-EGFP}

Fer2^{fTRG00336.sfGFP-TVPTBF}

fTRG 336

(Sarov et al., 2016)

Name Synonyms

Secondary FlyBase IDs

FBal0339338
FBal0299744

References (3)

Report Sections

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