FlyBase Allele Report: Dmel\His4[HisTA.H4K20R]

General Information

Symbol

Dmel\His4^HisTA.H4K20R

Species

D. melanogaster

Name

FlyBase ID

FBal0375496

Feature type

allele

Associated gene

His4

Associated Insertion(s)

Carried in Construct

PBac{12xHisTA.H4K20R}

Key Links

Transgenic product class

missense_variant

(Crain et al., 2022)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Crain et al., 2022)

Mutagen

in vitro construct

(Crain et al., 2022)

Progenitor genotype

Carried in construct

PBac{12xHisTA.H4K20R}

Cytology

Description

Mutated His4 gene (amino acid replacement K20R) in the context of a histone gene repeat unit.

(Crain et al., 2022)

Allele components

Component

Use(s)

Regulatory region(s)

His4

Encoded product / tool

His4

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Df(2L)His^C, His4^HisTA.H4K20R has increased mortality during development phenotype, enhanceable by His4r^15-4/His4r^15-4

(Crain et al., 2022)

Other

Statement

Reference

Df(2L)His^C, His4^HisTA.H4K20R has decreased body size | pupal stage phenotype

(Crain et al., 2022)

Df(2L)His^C, His4^HisTA.H4K20R has some die during P-stage phenotype

(Crain et al., 2022)

Df(2L)His^C, His4^HisTA.H4K20R has lethal - all die before end of P-stage phenotype

(Crain et al., 2022)

Df(2L)His^C, His4^HisTA.H4K20R has majority die during larval stage phenotype

(Crain et al., 2022)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

H4^K20R

(Crain et al., 2024)

His4^HisTA.H4K20R

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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