FlyBase Allele Report: Dmel\His4r[15-4]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\His4r^15-4

General Information

Symbol

Dmel\His4r^15-4

Species

D. melanogaster

Name

FlyBase ID

FBal0368286

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Armstrong et al., 2018)

Mutagen

(Armstrong et al., 2018)

Progenitor genotype

Cytology

Description

A 721-bp deletion spanning the entire His4r CDS.

(Armstrong et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

His4r^15-4/His4r^S9 is an enhancer of increased mortality during development phenotype of Df(2L)His^C, His4^HisTA.H4K20A

(Crain et al., 2022)

His4r^15-4/His4r^K20A is an enhancer of increased mortality during development phenotype of Df(2L)His^C, His4^HisTA.H4K20A

(Crain et al., 2022)

His4r^15-4/His4r^15-4 is an enhancer of increased mortality during development phenotype of Df(2L)His^C, His4^HisTA.H4K20R

(Crain et al., 2022)

Other

Statement

Reference

Df(2L)His^C, His4^HisTA.H4K20A, His4r^15-4/His4r^K20A has lethal - all die before end of P-stage phenotype

(Crain et al., 2022)

Df(2L)His^C, His4^HisTA.H4K20A, His4r^15-4/His4r^K20A has majority die during larval stage phenotype

(Crain et al., 2022)

Phenotype Manifest In

Other

Statement

Reference

Df(2L)His^C, His4^HisTA.H4K20A, His4r^15-4 has interommatidial bristle phenotype

(Crain et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

His4r^15-4

(Crain et al., 2022, Armstrong et al., 2018)

His4r^null

(Crain et al., 2024)

His4r^Δ

(Armstrong et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections