FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DroSK3
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General Information
Symbol
Dmel\DroSK3
Species
D. melanogaster
Name
FlyBase ID
FBal0375859
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Mutagen
Nature of the Allele
Progenitor genotype
Cytology
Description

A complex aberrant locus that disrupts 11 amino acid residues of the mature N-terminal Drosocin peptide, resulting in a truncated Drosocin peptide lacking its critical O-glycosylated Threonine. However, the deletion later continues in the same reading frame to include the RVRR furin cleavage site and C-terminus of the precursor protein, resulting in normal expression and secretion of the C-terminal ('Buletin') peptide.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Inserted_sequence:

ACTCTGTGG

Comment:

The deleted region is replaced with ACTCTGTGG. The net result is the deletion and substitution of 12 residues with 4 novel amino acids (HSVA) and then the reading frame resumes again.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)