FB2026_02 , released June 18, 2026
Allele: Dmel\GαoG203R
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General Information
Symbol
Dmel\GαoG203R
Species
D. melanogaster
Name
FlyBase ID
FBal0385330
Feature type
allele
Associated gene
Dmel\Gαo
Associated Insertion(s)
TI{TI}GαoG203R
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Larasati et al., 2022)
Mutagen
cre recombinase
(Larasati et al., 2022)
Progenitor genotype
TI{TI}Gαo47dsRed
(Larasati et al., 2022)
Associated Insertion(s)
TI{TI}GαoG203R
Cytology
Description

The G203R mutation has been introduced into endogenous Gαo.

(Larasati et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:10,461,109..10,461,109 [+]
Nucleotide change:

G10461109C

Reported nucleotide change:

G?C

Amino acid change:

G203R | Galphao-PA; G203R | Galphao-PB; G203R | Galphao-PC; G203R | Galphao-PD; G203R | Galphao-PE; G203R | Galphao-PF; G203R | Galphao-PG; G203R | Galphao-PH; G203R | Galphao-PI

Reported amino acid change:

G203R

Comment:

Analogous mutation in human GNAO1 implicated in cerebellar atrophy, visual impairment, and psychomotor retardation (FBhh0001481) and neurological disorders, GNAO1-related (FBhh0001127); the G203R mutation has been introduced into endogenous Gαo.

(Larasati et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  developmental and epileptic encephalopathy 17
      CEC
      (Larasati et al., 2022)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Larasati et al., 2022)
      GNAO1:p.Gly203Arg
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: 66115
      Comments concerning this variant
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      GαoG203R
      (Larasati et al., 2022)
      dGaoG203R
      (Larasati et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)