FB2026_02 , released June 18, 2026
Allele: Dmel\HisTko
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General Information
Symbol
Dmel\HisTko
Species
D. melanogaster
Name
FlyBase ID
FBal0385603
Feature type
allele
Associated gene
Dmel\HisT
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Xie et al., 2022)
Mutagen
CRISPR/Cas9
(Xie et al., 2022)
Progenitor genotype
Cytology
Description

A 2857 base pair deletion in the HisT gene, leading to a frame shift of the spliced HisT mRNA and a truncation of the protein.

(Xie et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:7,603,156..7,606,012 [-]
Comment:

A 2857 base pair deletion starting at aa26 of HisT. This leads to a frame shift and a early translation termination after the addition of thirty novel amino acids

Inserted_sequence:

AGTC

(Xie et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HisTko
      histko
      (Xie et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)