FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\sloKO
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General Information
Symbol
Dmel\sloKO
Species
D. melanogaster
Name
FlyBase ID
FBal0388534
Feature type
allele
Associated gene
Dmel\slo
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Xie et al., 2023)
Progenitor genotype
Cytology
Description

Frameshift mutation: 2bp deletion in codon 85, resulting in a truncated protein.

(Xie et al., 2023)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:24,669,746..24,669,747 [+]
Comment:

A 2bp deletion in codon 85 of of most slo isoforms (or codon 68 in the others) leads to a frameshift and early translation termination.

(Xie et al., 2023)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  high grade glioma
      modeled by RafCA.UAS.cUa
      (Xie et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sloKO
      (Xie et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)