FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Doa2C
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General Information
Symbol
Dmel\Doa2C
Species
D. melanogaster
Name
FlyBase ID
FBal0391494
Feature type
allele
Associated gene
Dmel\Doa
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    6bp deletion of two codons (MP) corresponding to residues 12 and 13 of the RJ, RN, RT and RU transcripts encoding the 69 kD Doa protein isoform expressed only in female bodies (but in the heads of both sexes).

    (Rabinow, 2023.6.12)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    3R:28,888,359..28,888,364 [+]
    Comment:

    Reported as a 6bp deletion of two codons (MP) corresponding to residues 12 and 13 of the RJ, RN, RT and RU transcripts of Doa. Codons MP are actually residues 11 and 12 and that is where the deletion has been mapped.

    (Rabinow, 2023.6.12)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygotes show reduced viability and fertility. Progeny of homozygous females have frequent embryonic cuticular defects, which are not rescued by being fertilized by wild type males.

        (Rabinow, 2023.6.12)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        NOT Suppressor of
        Statement
        Reference

        Doa2C is a non-suppressor of phenotype of wa

        (Rabinow, 2023.6.12)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Doa2C
        (Rabinow, 2023.6.12)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)