FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SerTTMKO
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General Information
Symbol
Dmel\SerTTMKO
Species
D. melanogaster
Name
FlyBase ID
FBal0392341
Feature type
allele
Associated gene
Dmel\SerT
Associated Insertion(s)
TI{TI}SerTTMKO
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Bonanno and Krantz, 2023)
gene targeting by homologous recombination
(Bonanno and Krantz, 2023)
Progenitor genotype
Associated Insertion(s)
TI{TI}SerTTMKO
Cytology
Description

Deletion of approximately 2.6kb that removes DNA coding for most of the first and second transmembrane domains of SerT and simultaneously induces a frameshift in the coding sequence. A single loxP site is present at the site of the deletion.

(Bonanno and Krantz, 2023)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  generalized anxiety disorder
      CEA
      (Bonanno and Krantz, 2023)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SerTTMKO
      dSERTTMKO
      (Bonanno and Krantz, 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)