FlyBase Gene Report: Dmel\SerT

General Information

Symbol

Dmel\SerT

Species

D. melanogaster

Name

Serotonin transporter

Annotation Symbol

CG4545

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010414

Gene Model Status

Current

Stock Availability

28 publicly available

Gene Summary

Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals. (UniProt, P51905)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dSERT

Key Links

Genomic Location

Cytogenetic map

60C8-60C8

Sequence location

2R:24,404,595..24,411,074 [-]

Recombination map

2-106

RefSeq locus

NT_033778 REGION:24404595..24411074

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables monoamine transmembrane transporter activity

inferred from direct assay

(Porzgen et al., 2001)

enables serotonin:sodium:chloride symporter activity

inferred from direct assay

(Park et al., 2006, Petersen and DeFelice, 1999)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables serotonin binding

inferred from biological aspect of ancestor with PANTHER:PTN002481010

(GO Reference Genome Project, 2011-)

enables serotonin:sodium:chloride symporter activity

inferred from biological aspect of ancestor with PANTHER:PTN002481010

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in monoamine transport

inferred from direct assay

(Porzgen et al., 2001)

involved_in serotonin transport

inferred from direct assay

(Petersen and DeFelice, 1999)

involved_in serotonin uptake

inferred from direct assay

(Park et al., 2006)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in amino acid transport

inferred from biological aspect of ancestor with PANTHER:PTN000907004

(GO Reference Genome Project, 2011-)

involved_in serotonin uptake

inferred from biological aspect of ancestor with PANTHER:PTN002481010

(GO Reference Genome Project, 2011-)

involved_in sodium ion transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000177662

(GO Reference Genome Project, 2011-)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in axon terminus

inferred from direct assay

(Park et al., 2006)

located_in axon

inferred from direct assay

(Park et al., 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR000175

(InterPro Project Members, 2004-)

is_active_in neuron projection

inferred from biological aspect of ancestor with PANTHER:PTN002481010

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000177662

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from sequence or structural similarity with UniProtKB:P31645

(Corey et al., 1994)

is_active_in synapse

inferred from biological aspect of ancestor with PANTHER:PTN002481010

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SLC6 FAMILY OF SODIUM/CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTERS

Protein Family (UniProt)

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (P51905)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

serotonin:sodium:chloride symporter activity
RHEA 51196:

Summaries

Gene Group (FlyBase)

SLC6 FAMILY OF SODIUM/CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTERS -: Solute carrier family 6 (SLC6) members are Na⁺/Cl^--dependent transporters of extracellular neurotransmitters, amino acids and osmolytes across the plasma membrane into the cytosol. (Adapted from FBrf0193583).

Protein Function (UniProtKB)

Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals.

(UniProt, P51905)

Summary (Interactive Fly)

regulates serotonergic neurotransmission by retrieving released serotonin and replenishing vesicular stores - expressed in brain and CNS

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SerT for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P51905)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Stop-codon suppression (UGA) postulated; FBrf0243886.

Gene model reviewed during 6.32

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SerT-RA

FBtr0072362

NM_079122

3183

622

SerT-RB

FBtr0343316

NM_001299910

3725

622

SerT-RC

FBtr0479819

NM_001382130

3183

768

Additional Transcript Data and Comments

Reported size (kB)

3.3 (northern blot)

(Corey et al., 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

SerT-PA

FBpp0072269

69.3

622

4.98

FBpp0309974

69.3

622

4.98

FBpp0428152

85.7

768

6.79

QJC18740

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

622 aa isoforms: SerT-PA, SerT-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

581 (aa); 67 (kD predicted)

(Corey et al., 1994)

622 (aa); 69 (kD predicted)

(Demchyshyn et al., 1994)

Comments

SerT protein is detected indirectly, via serotonin uptake; antibody used is specific to 5HT.

(Couch et al., 2004)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SerT using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.43

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval central nervous system | restricted

(Demchyshyn et al., 1994)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic central brain neuron

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 15

serotonergic neuron of larval ventral nerve cord

(Couch et al., 2004)

embryonic stage 15 -- 17

presumptive embryonic/larval central nervous system | restricted

(Demchyshyn et al., 1994)

adult stage

adult serotonergic PMPD neuron

(Giang et al., 2011)

adult serotonergic PMPM neuron

(Giang et al., 2011)

adult serotonergic PLP neuron

(Giang et al., 2011)

adult serotonergic LP2 neuron

(Giang et al., 2011)

adult CSD interneuron

(Giang et al., 2011)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

(Romero-Calderon et al., 2007, Corey et al., 1994)

adult thorax

Comment: Thorax and abdomen assayed together. Bands of 1.4 and 2.2kb detected.

(Romero-Calderon et al., 2007)

adult abdomen

Comment: Thorax and abdomen assayed together. Bands of 1.4 and 2.2kb detected.

(Romero-Calderon et al., 2007)

Additional Descriptive Data

SerT-mRNA expression resembles the distribution pattern of serotonin in the larval and adult CNS.

(Giang et al., 2011)

Embryonic expression of SerT mRNA in the ventral nerve cord is observed in two serotonergic neurons per hemisegment.

(Couch et al., 2004)

SerT transcripts are detected in RNA from adult heads but not in RNA from embryos or adult bodies.

(Corey et al., 1994)

SerT transcripts are detected in a restricted number of cell bodies in the ventral ganglion and the brain in late embryos. The cell bodies are just ventral to the neuropil and are generally clustered. Each suboesophageal hemiganglion contains three positive cell bodies. Each thoracic and abdominal hemiganglion contains two stained cell bodies, except A8, which contains a single stained cell body.

(Demchyshyn et al., 1994)

Marker for

serotonergic neuron

(Couch et al., 2004)

Subcellular Localization

CV Term

Polypeptide Expression

immunodetection (other than il)

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15 -- 16

serotonergic neuron of larval ventral nerve cord

(Couch et al., 2004)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

Additional Descriptive Data

SerT-protein expression resembles the distribution pattern of serotonin in the larval and adult CNS.

(Giang et al., 2011)

Embryonic activity of SerT protein in the ventral nerve cord is observed in two serotonergic neurons per hemisegment. SerT protein activity is not observed until after the axonal growth cones have crossed the ventral midline.

(Couch et al., 2004)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in axon terminus

inferred from direct assay

(Park et al., 2006)

located_in axon

inferred from direct assay

(Park et al., 2006)

Expression Deduced from Reporters

Reporter: P{GMR50H05-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

serotonergic neuron of fruitless expressing neuron | subset

(Sitaraman et al., 2017)

fruitless expressing neuron | subset

(Sitaraman et al., 2017)

adult brain | restricted

(Sitaraman et al., 2017)

serotonergic neuron | subset

(Sitaraman et al., 2017, Albin et al., 2015)

Reporter: P{SerT-GAL4.Si6}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | restricted

(Sitaraman et al., 2017)

serotonergic SE2 neuron | subset

(Sitaraman et al., 2017)

serotonergic SE3 neuron | subset

(Sitaraman et al., 2017)

serotonergic neuron of fruitless expressing neuron | subset

(Sitaraman et al., 2017)

Reporter: TI{2A-lexA::p65}SerT^2A-lexA

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult serotonergic neuron | subset

(Deng et al., 2019)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SerT in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SerT

View exonic expression by tissue for Dmel\SerT

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010414

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37895/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010414

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010414

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010414

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4545

Flygut - An atlas of the Drosophila adult midgut

FBgn0010414

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\SerT

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SerT

Transgenic constructs containing regulatory region of SerT

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel6278

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

SerT^GD3824

viable, with Scer\GAL4^Mef2.PR

SerT^GD3824

viable, with Scer\GAL4^pnr-MD237

SerT^GD3824

viable, with Scer\GAL4^tin.CΔ4

SerT^GD3824

Sterility

Allele

fertile

SerT^2xFLAG

Other Phenotypes

Allele

abnormal behavior | adult stage

abnormal locomotor behavior | adult stage, with Scer\GAL4^nSyb.PS

SerT^GD3824

abnormal phototaxis | adult stage, with Scer\GAL4^nSyb.PS

SerT^UAS.cPa

increased cell death | larval stage, with Scer\GAL4^GMR.PU

SerT^KK108310

increased occurrence of cell division | larval stage, with Scer\GAL4^GMR.PU

SerT^KK108310

visible | adult stage, with Scer\GAL4^GMR.PU

Phenotype manifest in

Allele

cone cell | larval stage, with Scer\GAL4^GMR.PU

SerT^KK108310

eye, with Scer\GAL4^GMR.PU

eye disc | larval stage, with Scer\GAL4^GMR.PU

SerT^KK108310

interommatidial bristle | absent | adult stage, with Scer\GAL4^GMR.PU

ommatidium | adult stage, with Scer\GAL4^GMR.PU

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\SLC6A4

10 of 14

Yes

7 of 14

7 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (20)

Rnor\Slc6a4

10 of 14

Yes

7 of 14

7 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

Rnor\Slc6a18

2 of 14

Rnor\Slc6a19

2 of 14

Rnor\Slc6a20

2 of 14

Mus musculus (laboratory mouse) (21)

Mmus\Slc6a4

11 of 14

Yes

7 of 14

7 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Xenopus tropicalis (Western clawed frog) (26)

Xtro\slc6a4l

9 of 13

Yes

Xtro\lyl1

8 of 13

Yes

Xtro\slc6a4

6 of 13

Yes

Xtro\slc6a2

3 of 13

Xtro\slc6a3

3 of 13

Xtro\slc6a6

3 of 13

Yes

Xtro\slc6a8l

3 of 13

Yes

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100490052

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\tnip1

1 of 13

Xtro\XB5944457

1 of 13

Xtro\zmiz2

1 of 13

Danio rerio (Zebrafish) (36)

Drer\slc6a4b

12 of 14

Yes

Drer\slc6a4a

11 of 14

Yes

Drer\slc6a3

7 of 14

Drer\slc6a2

6 of 14

Drer\si:ch211-117c9.5

4 of 14

Drer\slc6a8

4 of 14

Drer\slc6a13

4 of 14

Drer\si:ch211-132b12.1

3 of 14

Drer\si:ch211-132b12.2

3 of 14

Drer\si:ch211-132b12.3

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Drer\si:ch211-132b12.6

2 of 14

Drer\si:ch211-225b11.1

2 of 14

Drer\si:ch211-283g2.1

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Drer\si:ch211-132b12.4

1 of 14

Yes

Drer\slc6a15

1 of 14

Drer\slc6a16b

1 of 14

Drer\slc6a18

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\mod-5

13 of 14

Yes

7 of 14

3 of 14

3 of 14

3 of 14

Yes

Cele\snf-7

3 of 14

Cele\snf-9

3 of 14

Cele\snf-10

3 of 14

Yes

Cele\snf-11

3 of 14

Cele\snf-12

3 of 14

Cele\Y43D4A.1

3 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (22)

Agam\AgaP_AGAP010621

12 of 12

Yes

6 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

Yes

Agam\AgaP_AGAP000493

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Agam\AgaP_AGAP011279

2 of 12

Agam\AgaP_AGAP012565

2 of 12

Yes

Agam\AgaP_AGAP000494

1 of 12

Yes

Agam\AgaP_AGAP001194

1 of 12

Agam\AgaP_AGAP010862

1 of 12

Agam\AgaP_AGAP012290

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:SerT. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (21)

DAT

8 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

Gat

5 of 13

ine

5 of 13

List

5 of 13

NAAT1

5 of 13

Ntl

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

bdg

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

anxiety modulators, fly wall-following model

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 4 )

Allele

Disease

Evidence

References

SerT^GD3824

model of generalized anxiety disorder

CEA

(Mohammad et al., 2016)

SerT^KK108310

model of generalized anxiety disorder

CEA

(Mohammad et al., 2016)

SerT¹⁶

model of depressive disorder

CEA

(Dunham et al., 2024)

model of generalized anxiety disorder

CEA

(Bonanno and Krantz, 2023)

SerT^TMKO

model of generalized anxiety disorder

CEA

(Bonanno and Krantz, 2023)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SLC6A4; solute carrier family 6 member 4

model of anxiety disorder

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

SerT^MI02578

ameliorates Parkinson's disease 6

modeled by Pink1^B9

(Zárate et al., 2022)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC6A4; solute carrier family 6 member 4

10 of 14

182138

anxiety disorder

SLC6A2; solute carrier family 6 member 2

7 of 14

163970

ORTHOSTATIC INTOLERANCE; ORSTI

postural orthostatic tachycardia syndrome

SLC6A3; solute carrier family 6 member 3

7 of 14

SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER, DOPAMINE), MEMBER 3; SLC6A3

classic dopamine transporter deficiency syndrome

SLC6A6; solute carrier family 6 member 6

4 of 14

186854

HYPOTAURINEMIC RETINAL DEGENERATION AND CARDIOMYOPATHY; HTRDC

SLC6A8; solute carrier family 6 member 8

4 of 14

300036

CEREBRAL CREATINE DEFICIENCY SYNDROME 1; CCDS1

cerebral creatine deficiency syndrome 1

SLC6A11; solute carrier family 6 member 11

4 of 14

607952

SLC6A12; solute carrier family 6 member 12

4 of 14

603080

SLC6A13; solute carrier family 6 member 13

4 of 14

615097

SLC6A1; solute carrier family 6 member 1

3 of 14

SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER, GABA), MEMBER 1; SLC6A1

MYOCLONIC-ATONIC EPILEPSY; MAE

myoclonic-atonic epilepsy

SLC6A5; solute carrier family 6 member 5

3 of 14

604159

HYPEREKPLEXIA 3; HKPX3

hyperekplexia 3

SLC6A7; solute carrier family 6 member 7

3 of 14

606205

SLC6A9; solute carrier family 6 member 9

3 of 14

601019

SLC6A14; solute carrier family 6 member 14

3 of 14

300444

SLC6A15; solute carrier family 6 member 15

3 of 14

607971

SLC6A16; solute carrier family 6 member 16

3 of 14

607972

SLC6A17; solute carrier family 6 member 17

3 of 14

610299

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 48; MRT48

autosomal recessive intellectual developmental disorder 48

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

SerT

suppressible

Diap1

(Pham et al., 2020)

SerT

suppressible

Pi3K92E

(Pham et al., 2020)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010414

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Serotonin clearance from the synaptic cleft

Class of Gene

gene_with_stop_codon_read_through

(FlyBase Genome Annotators, 2020, FlyBase Genome Annotators, 2019-)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-106

Cytogenetic map

60C8-60C8

Sequence location

2R:24,404,595..24,411,074 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60C8-60C8

Limits computationally determined from genome sequence between P{PZ}bs⁰³²⁶⁷&P{lacW}l(2)k10502^k10502 and P{lacW}Nurf-38^k16102

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60C-60C

(Niznik, 1993.12.30)

Experimentally Determined Recombination Data

Location

2-106

(FlyBase, 2016)

2-110.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (28)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

24463

P{UAS-EGFP.SerT}1, w^*

24464

w^*; P{UAS-SerT.P}19-4

84434

TI{2A-lexA::p65}SerT^2A-lexA

38749

w¹¹¹⁸; P{GMR50E07-GAL4}attP2

38750

w¹¹¹⁸; P{GMR50E11-GAL4}attP2

38764

w¹¹¹⁸; P{GMR50H05-GAL4}attP2

94650

w¹¹¹⁸; P{GMR50H05-lexA}attP2

52856

w¹¹¹⁸; P{GMR50H05-lexA}attP40

54151

w¹¹¹⁸; P{GMR50E07-lexA}attP40

Korea

14859

P{VT021853-GAL4}attP2

VDRC

v100584

P{KK108310}VIE-260B

v11346

w¹¹¹⁸; P{GD3824}v11346

More stocks available...

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (12)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE10485

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010414

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RE65250

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010414

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Daubert et al., 2010)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

Based on an alignment of the nucleotide sequence of the cDNA clone from FBrf0072947 and FBrf0068457 the two cDNA's represent the same gene.

(Guastella, 1995.8.25)

The nucleotide sequence from FBrf0072947 and FBrf0068457, encoding a functional fly Serotonin like transporter, are identical.

(Niznik, 1995.8.24)

SerT possesses a number of functional properties of the Na⁺/Cl^- superfamiliy, including a dependence on Na and Cl, a high affinity for 5HT and electrogenicity. SerT is coccaine-sensitive, possessing an unusual pharmacological profile.

(Corey et al., 1994)

Molecular characterisation of SerT.

(Demchyshyn et al., 1994)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: SerT CG4545

(Wang, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

CG4545

(Mao et al., 2024, Frenkel et al., 2017, Han et al., 2017, Hosono et al., 2015, Kaiser, 2009.1.22, Keleman et al., 2009.8.5, Perkins et al., 2009, Miller et al., 2008, Romero-Calderon et al., 2007)

DmSERT

(Panneels et al., 2011)

DmSerT

(Miller et al., 2008)

SERT

(Bonanno et al., 2024, Rosikon et al., 2023, Carvajal-Oliveros and Campusano, 2020, Shankar et al., 2015, Gu et al., 2006, Henry et al., 2006, Couch et al., 2002, Filippov et al., 2002, Rieff and Condron, 2001)

SerT

(Lee et al., 2025, Shi et al., 2025, Walsh et al., 2025, Mallick, 2024.6.28, Bossen et al., 2023, Metaxakis et al., 2023, Ceder and Fredriksson, 2022, Corrales et al., 2022, Velten et al., 2022, Chow et al., 2021, Vogt et al., 2021, Chvilicek et al., 2020, FlyBase Genome Annotators, 2020, Jajoo et al., 2020, Subaraja et al., 2020, Brunet Avalos et al., 2019, Deng et al., 2019, FlyBase Genome Annotators, 2019-, Meissner et al., 2019, Rao and Deng, 2019.10.23, Shih et al., 2019, Croset et al., 2018, Davie et al., 2018, Frenkel et al., 2017, Han et al., 2017, Sitaraman et al., 2017, Crocker et al., 2016, Mohammad et al., 2016, Gene Disruption Project members, 2015-, Short and Lazzaro, 2013, Stotz and Clapham, 2012, Kaiser, 2009.1.22, Friedman and Perrimon, 2006, Stroschein-Stevenson et al., 2006, Thimgan et al., 2006)

Sert

(He et al., 2020)

dSERT1

(Corey et al., 1994)

dSerT

(Romero-Calderon et al., 2007, Novotny et al., 2002)

dSert

(Xu et al., 2016)

dmSERT

(Davis et al., 2016)

dsert

(Giang et al., 2011)

serT

(Dierick and Greenspan, 2007)

Name Synonyms

Drosophila Serotonin transporter

(Petersen and DeFelice, 1999)

Drosophila serotonin transporter

(Park et al., 2006)

Serotonin transporter

(Shafer, 2025, Gu et al., 2006)

cocaine-sensitive serotonin transporter

(Corey, 1993.9.30)

serotonin transporter

(Daubert et al., 2010, Thimgan et al., 2006, Niznik, 1993.12.30)

Secondary FlyBase IDs

FBgn0011835

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37895

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P51905

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P51905

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P51905

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010414

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37895/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010414

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010414

FlyMine - An integrated database for Drosophila genomics

FBgn0010414

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4545

MARRVEL_MODEL - MARRVEL (model organism gene)

37895

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010414

DroID - A comprehensive database of gene and protein interactions.

FBgn0010414

DRSC - Results frm RNAi screens

FBgn0010414

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010414

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010414

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4545

Flygut - An atlas of the Drosophila adult midgut

FBgn0010414

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010414

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002347

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Serotonin clearance from the synaptic cleft

References (132)

The following external sites may use different assemblies or annotations than FlyBase.

-0.43

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