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FB2021_03, released June 15, 2021

Gene: Dmel\CG15279

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General Information
Symbol
Dmel\CG15279
Species
D. melanogaster
Name
Annotation Symbol
CG15279
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028886
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

BG:DS03431.1

Key Links
Genomic Location
Cytogenetic map
35B6-35B6
Sequence location
2L:14,844,993..14,851,749 [-]
Recombination map
2-50
RefSeq locus
NT_033779 REGION:14844993..14851749
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables amino acid:cation symporter activity
inferred from sequence model
(Thimgan et al., 2006)
enables amino acid:sodium symporter activity
inferred from biological aspect of ancestor with PANTHER:PTN002267127
(assigned by GO_Central )
(Gaudet et al., 2011)
enables L-amino acid transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN002267127
(assigned by GO_Central )
(Gaudet et al., 2011)
enables neurotransmitter transmembrane transporter activity
inferred from sequence or structural similarity with FLYBASE:DAT; FB:FBgn0034136
(Romero-Calderon et al., 2007)
Biological Process (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in amino acid transmembrane transport
inferred from sequence model
(Thimgan et al., 2006)
involved_in neurotransmitter transport
inferred from sequence or structural similarity with FLYBASE:DAT; FB:FBgn0034136
(Romero-Calderon et al., 2007)
involved_in sodium ion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000177662
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence model
(Thimgan et al., 2006)
is_active_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000177662
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SLC6 FAMILY OF SODIUM/CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTERS -
Solute carrier family 6 (SLC6) members are Na+/Cl--dependent transporters of extracellular neurotransmitters, amino acids and osmolytes across the plasma membrane into the cytosol. (Adapted from FBrf0193583).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\CG15279 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG15279-RA
FBtr0080686
NM_135882
2110
639
CG15279-RB
FBtr0080685
NM_165093
2531
639
CG15279-RD
FBtr0300845
NM_001014484
2513
633
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG15279-PA
FBpp0080248
71.4
639
8.02
NP_609726
AAF53415
CG15279-PB
FBpp0080247
71.4
639
8.02
NP_723885
AAN10882
CG15279-PD
FBpp0290069
70.4
633
7.62
NP_001014484
AAX52665
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

639 aa isoforms: CG15279-PA, CG15279-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG15279 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Romero-Calderon et al., 2007)
adult thorax

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)
adult abdomen

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG15279 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG15279
Transgenic constructs containing regulatory region of CG15279
Aberrations (Deficiencies and Duplications) ( 3 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC6A7
4 of 15
Yes
No
Hsap\SLC6A9
4 of 15
Yes
No
Hsap\SLC6A15
4 of 15
Yes
No
Hsap\SLC6A16
4 of 15
Yes
Yes
Hsap\SLC6A17
4 of 15
Yes
No
Hsap\SLC6A1
3 of 15
No
No
Hsap\SLC6A2
3 of 15
No
No
Hsap\SLC6A3
3 of 15
No
No
13  
Hsap\SLC6A4
3 of 15
No
No
1  
Hsap\SLC6A5
3 of 15
No
No
1  
Hsap\SLC6A6
3 of 15
No
No
Hsap\SLC6A8
3 of 15
No
No
Hsap\SLC6A11
3 of 15
No
No
Hsap\SLC6A12
3 of 15
No
No
Hsap\SLC6A13
3 of 15
No
No
Hsap\SLC6A14
3 of 15
No
No
Hsap\SLC6A18
2 of 15
No
No
Hsap\SLC6A19
2 of 15
No
No
1  
Hsap\SLC6A20
2 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc6a7
4 of 15
Yes
No
Mmus\Slc6a8
4 of 15
Yes
No
Mmus\Slc6a9
4 of 15
Yes
No
Mmus\Slc6a15
4 of 15
Yes
No
Mmus\Slc6a21
4 of 15
Yes
Yes
Mmus\Slc6a2
3 of 15
No
No
Mmus\Slc6a3
3 of 15
No
No
Mmus\Slc6a4
3 of 15
No
No
Mmus\Slc6a5
3 of 15
No
No
Mmus\Slc6a6
3 of 15
No
No
Mmus\Slc6a11
3 of 15
No
No
Mmus\Slc6a12
3 of 15
No
No
Mmus\Slc6a13
3 of 15
No
No
Mmus\Slc6a14
3 of 15
No
No
Mmus\Slc6a16
3 of 15
No
Yes
Mmus\Slc6a17
3 of 15
No
No
Mmus\Slc6a1
2 of 15
No
No
Mmus\Slc6a18
2 of 15
No
No
Mmus\Slc6a19
2 of 15
No
No
Mmus\Slc6a20a
2 of 15
No
No
Mmus\Slc6a20b
2 of 15
No
No
Mmus\Wdr76
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (21)
Rnor\RGD1562492
4 of 13
Yes
Yes
Rnor\Slc6a7
4 of 13
Yes
No
Rnor\Slc6a9
4 of 13
Yes
Yes
Rnor\Slc6a16
4 of 13
Yes
Yes
Rnor\Slc6a17
4 of 13
Yes
No
Rnor\Slc6a1
3 of 13
No
No
Rnor\Slc6a2
3 of 13
No
No
Rnor\Slc6a3
3 of 13
No
No
Rnor\Slc6a4
3 of 13
No
No
Rnor\Slc6a5
3 of 13
No
No
Rnor\Slc6a6
3 of 13
No
No
Rnor\Slc6a11
3 of 13
No
No
Rnor\Slc6a12
3 of 13
No
No
Rnor\Slc6a13
3 of 13
No
No
Rnor\Slc6a14
3 of 13
No
No
Rnor\Slc6a15
3 of 13
No
No
Rnor\Slc6a8
2 of 13
No
No
Rnor\Slc6a18
2 of 13
No
No
Rnor\Slc6a19
2 of 13
No
No
Rnor\Slc6a20
2 of 13
No
No
Rnor\LOC103690061
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (23)
Xtro\slc6a7
4 of 12
Yes
Yes
Xtro\slc6a9
4 of 12
Yes
Yes
Xtro\LOC100127682
3 of 12
No
No
Xtro\slc6a1
3 of 12
No
No
Xtro\slc6a2
3 of 12
No
No
Xtro\slc6a3
3 of 12
No
No
Xtro\slc6a4
3 of 12
No
No
Xtro\slc6a5
3 of 12
No
No
Xtro\slc6a6
3 of 12
No
No
Xtro\slc6a8
3 of 12
No
No
Xtro\slc6a8
3 of 12
No
No
Xtro\slc6a12
3 of 12
No
Yes
Xtro\slc6a13
3 of 12
No
No
Xtro\slc6a14.2
3 of 12
No
No
Xtro\slc6a15
3 of 12
No
No
Xtro\slc6a17
3 of 12
No
No
Xtro\slc6a16
2 of 12
No
No
Xtro\slc6a19
2 of 12
No
No
Xtro\LOC100490052
1 of 12
No
Yes
Xtro\LOC100497766
1 of 12
No
Yes
Xtro\LOC101731472
1 of 12
No
Yes
Xtro\slc6a4
1 of 12
No
No
Xtro\slc6a14.1
1 of 12
No
Yes
Danio rerio (Zebrafish) (36)
Drer\slc6a7
4 of 15
Yes
Yes
Drer\slc6a9
4 of 15
Yes
No
Drer\slc6a15
4 of 15
Yes
No
Drer\slc6a16a
4 of 15
Yes
No
Drer\slc6a17
4 of 15
Yes
No
Drer\si:ch211-117c9.5
3 of 15
No
No
Drer\si:ch211-132b12.1
3 of 15
No
No
Drer\si:ch211-132b12.2
3 of 15
No
No
Drer\si:ch211-132b12.3
3 of 15
No
No
Drer\slc6a1b
3 of 15
No
No
Drer\slc6a1l
3 of 15
No
No
Drer\slc6a2
3 of 15
No
No
Drer\slc6a4a
3 of 15
No
No
Drer\slc6a4b
3 of 15
No
No
Drer\slc6a5
3 of 15
No
No
Drer\slc6a6a
3 of 15
No
No
Drer\slc6a8
3 of 15
No
No
Drer\slc6a11a
3 of 15
No
No
Drer\slc6a11b
3 of 15
No
No
Drer\slc6a13
3 of 15
No
No
Drer\slc6a14
3 of 15
No
No
Drer\slc6a22.1
3 of 15
No
No
Drer\slc6a22.2
3 of 15
No
No
Drer\si:ch211-132b12.6
2 of 15
No
No
Drer\si:ch211-225b11.1
2 of 15
No
No
Drer\si:ch211-283g2.1
2 of 15
No
No
Drer\slc6a1a
2 of 15
No
No
Drer\slc6a3
2 of 15
No
No
Drer\slc6a6b
2 of 15
No
No
Drer\slc6a16b
2 of 15
No
No
Drer\slc6a18
2 of 15
No
No
Drer\slc6a19a.1
2 of 15
No
No
Drer\slc6a19a.2
2 of 15
No
No
Drer\slc6a19b
2 of 15
No
No
Drer\zgc:158427
2 of 15
No
No
Drer\si:ch211-132b12.4
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (16)
Cele\snf-2
4 of 15
Yes
No
Cele\snf-7
4 of 15
Yes
No
Cele\snf-9
4 of 15
Yes
Yes
Cele\snf-12
4 of 15
Yes
No
Cele\snf-5
3 of 15
No
No
Cele\snf-6
3 of 15
No
No
Cele\Y43D4A.1
3 of 15
No
Yes
Cele\dat-1
2 of 15
No
No
Cele\mod-5
2 of 15
No
No
Cele\snf-1
2 of 15
No
Yes
Cele\snf-3
2 of 15
No
No
Cele\snf-8
2 of 15
No
Yes
Cele\snf-11
2 of 15
No
No
Cele\C09E8.1
1 of 15
No
No
Cele\F56F4.3
1 of 15
No
No
Cele\snf-10
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919042X )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000176
Drosophila simulans
Dsim\GD21984
Drosophila sechellia
Dsec\GM14665
Drosophila erecta
Dere\GG24238
Drosophila yakuba
Dyak\GE24820
Drosophila ananassae
Dana\GF15004
Drosophila pseudoobscura pseudoobscura
Dpse\GA29219
Drosophila pseudoobscura pseudoobscura
Dpse\GA13623
Drosophila persimilis
Dper\GL25743
Drosophila willistoni
Dwil\GK18075
Drosophila virilis
Dvir\GJ11796
Drosophila mojavensis
Dmoj\GI17341
Drosophila grimshawi
Dgri\GH10830
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915001H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022945
Musca domestica
House fly
Mdoa\17022944
Musca domestica
House fly
Mdoa\17014028
Musca domestica
House fly
Mdoa\17023734
Musca domestica
House fly
Mdoa\17006782
Musca domestica
House fly
Mdoa\17010657
Musca domestica
House fly
Mdoa\17010819
Musca domestica
House fly
Mdoa\17010821
Musca domestica
House fly
Mdoa\17014827
Musca domestica
House fly
Mdoa\17021245
Glossina morsitans
Tsetse fly
Gmor\GMOY009326
Glossina morsitans
Tsetse fly
Gmor\GMOY010066
Glossina morsitans
Tsetse fly
Gmor\GMOY009386
Glossina morsitans
Tsetse fly
Gmor\GMOY001362
Glossina morsitans
Tsetse fly
Gmor\GMOY007447
Glossina morsitans
Tsetse fly
Gmor\GMOY009388
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10479
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04338
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10481
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10480
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02831
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07364
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13138
Mayetiola destructor
Hessian fly
Mdes\Mdes002926
Mayetiola destructor
Hessian fly
Mdes\Mdes008594
Mayetiola destructor
Hessian fly
Mdes\Mdes005733
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003627
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL018304
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003624
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL015287
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003626
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008424
Anopheles darlingi
American malaria mosquito
Adar\ADAC005212
Anopheles darlingi
American malaria mosquito
Adar\ADAC005210
Anopheles darlingi
American malaria mosquito
Adar\ADAC005214
Anopheles darlingi
American malaria mosquito
Adar\ADAC005215
Anopheles darlingi
American malaria mosquito
Adar\ADAC005213
Anopheles gambiae
Malaria mosquito
Agam\AGAP010861
Anopheles gambiae
Malaria mosquito
Agam\AGAP010865
Anopheles gambiae
Malaria mosquito
Agam\AGAP010857
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019020
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012067
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019018
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012063
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ020187
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012066
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012065
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019526
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019019
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02XG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007228
Danaus plexippus
Monarch butterfly
Dple\DPOGS204331-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS204332-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004634
Apis florea
Little honeybee
Aflo\3329279268
Apis florea
Little honeybee
Aflo\3329279300
Apis florea
Little honeybee
Aflo\2147491217
Apis florea
Little honeybee
Aflo\2147590163
Apis mellifera
Western honey bee
Amel\GB51833
Apis mellifera
Western honey bee
Amel\GB51845
Apis mellifera
Western honey bee
Amel\LOC725420
Apis mellifera
Western honey bee
Amel\GB51844
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17943
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11135
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11132
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11133
Bombus terrestris
Buff-tailed bumblebee
Bter\15209009
Bombus terrestris
Buff-tailed bumblebee
Bter\15209010
Bombus terrestris
Buff-tailed bumblebee
Bter\15209011
Bombus terrestris
Buff-tailed bumblebee
Bter\15209012
Linepithema humile
Argentine ant
Lhum\LH15953
Linepithema humile
Argentine ant
Lhum\LH15938
Linepithema humile
Argentine ant
Lhum\LH12275
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002a2f
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002a30
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016556
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016555
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07033
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07032
Tribolium castaneum
Red flour beetle
Tcas\TC006378
Tribolium castaneum
Red flour beetle
Tcas\TC006379
Pediculus humanus
Human body louse
Phum\PHUM294590
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14616
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01ZN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008657
Strigamia maritima
European centipede
Smar\SMAR008484
Strigamia maritima
European centipede
Smar\SMAR009592
Strigamia maritima
European centipede
Smar\SMAR003062
Strigamia maritima
European centipede
Smar\SMAR007803
Strigamia maritima
European centipede
Smar\SMAR007234
Strigamia maritima
European centipede
Smar\SMAR015421
Strigamia maritima
European centipede
Smar\SMAR007877
Strigamia maritima
European centipede
Smar\SMAR002187
Strigamia maritima
European centipede
Smar\SMAR013482
Strigamia maritima
European centipede
Smar\SMAR011773
Strigamia maritima
European centipede
Smar\SMAR006384
Strigamia maritima
European centipede
Smar\SMAR011531
Strigamia maritima
European centipede
Smar\SMAR008124
Ixodes scapularis
Black-legged tick
Isca\ISCW013094
Ixodes scapularis
Black-legged tick
Isca\ISCW008752
Ixodes scapularis
Black-legged tick
Isca\ISCW023714
Ixodes scapularis
Black-legged tick
Isca\ISCW010973
Ixodes scapularis
Black-legged tick
Isca\ISCW005703
Ixodes scapularis
Black-legged tick
Isca\ISCW010971
Ixodes scapularis
Black-legged tick
Isca\ISCW017889
Ixodes scapularis
Black-legged tick
Isca\ISCW020003
Ixodes scapularis
Black-legged tick
Isca\ISCW016408
Ixodes scapularis
Black-legged tick
Isca\ISCW013626
Ixodes scapularis
Black-legged tick
Isca\ISCW023444
Ixodes scapularis
Black-legged tick
Isca\ISCW020974
Ixodes scapularis
Black-legged tick
Isca\ISCW023410
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58358.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77545.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61330.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72842.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74324.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67774.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57632.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61014.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur20g00590
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g08110
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g00580
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g04880
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g08610
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g02660
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g04170
Tetranychus urticae
Two-spotted spider mite
Turt\tetur18g00200
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g07840
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g02090
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304891
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_315258
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_42690
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_55141
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_35506
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_224133
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_314292
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_328816
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_60804
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48062
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_203728
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_188047
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_46779
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_203278
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302045
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08PX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a5-3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_018760gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Glyt
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gat_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_007581gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Glyt_6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a2_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_007205gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Glyt_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a13
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Glyt_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gat_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gat
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gat_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sert
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a5_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Taut
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a5_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a5-2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Glyt_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a5_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a2
Ciona intestinalis
Vase tunicate
Cint\LOC100178767
Ciona intestinalis
Vase tunicate
Cint\LOC100176370
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024700
Ciona intestinalis
Vase tunicate
Cint\LOC100179103
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008543
Ciona intestinalis
Vase tunicate
Cint\LOC100178874
Ciona intestinalis
Vase tunicate
Cint\LOC100187411
Ciona intestinalis
Vase tunicate
Cint\LOC100180033
Ciona intestinalis
Vase tunicate
Cint\LOC100183042
Ciona intestinalis
Vase tunicate
Cint\LOC100186059
Ciona intestinalis
Vase tunicate
Cint\LOC100176179
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021746
Ciona intestinalis
Vase tunicate
Cint\LOC100187294
Ciona intestinalis
Vase tunicate
Cint\slc6a17
Ciona intestinalis
Vase tunicate
Cint\LOC100176779
Ciona intestinalis
Vase tunicate
Cint\LOC100185022
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003845
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006841
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007757
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020950
Ciona intestinalis
Vase tunicate
Cint\LOC100177748
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005986
Gallus gallus
Domestic chicken
Ggal\LOC427923
Gallus gallus
Domestic chicken
Ggal\SLC6A18
Gallus gallus
Domestic chicken
Ggal\SLC6A9
Gallus gallus
Domestic chicken
Ggal\SLC6A4
Gallus gallus
Domestic chicken
Ggal\SLC6A20
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027982
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026545
Gallus gallus
Domestic chicken
Ggal\SLC6A11
Gallus gallus
Domestic chicken
Ggal\SLC6A14
Gallus gallus
Domestic chicken
Ggal\SLC6A12
Gallus gallus
Domestic chicken
Ggal\SLC6A17
Gallus gallus
Domestic chicken
Ggal\SLC6A13
Gallus gallus
Domestic chicken
Ggal\SLC6A5
Gallus gallus
Domestic chicken
Ggal\SLC6A15
Gallus gallus
Domestic chicken
Ggal\SLC6A6
Gallus gallus
Domestic chicken
Ggal\SLC6A7
Gallus gallus
Domestic chicken
Ggal\SLC6A1
Gallus gallus
Domestic chicken
Ggal\SLC6A2
Gallus gallus
Domestic chicken
Ggal\SLC6A19
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (22)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG1698
4 of 10
CG4476
4 of 10
CG8850
4 of 10
CG13796
4 of 10
DAT
4 of 10
Gat
4 of 10
ine
4 of 10
List
4 of 10
NAAT1
4 of 10
SerT
4 of 10
CG13793
3 of 10
CG13794
3 of 10
CG13795
3 of 10
CG33296
3 of 10
CG43066
3 of 10
GlyT
3 of 10
Ntl
3 of 10
bdg
2 of 10
blot
2 of 10
CG10804
2 of 10
CG31904
2 of 10
natalisin
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC6A7; solute carrier family 6 member 7
    4 of 15
    606205
        SLC6A9; solute carrier family 6 member 9
        4 of 15
        601019
          SLC6A15; solute carrier family 6 member 15
          4 of 15
          607971
              SLC6A16; solute carrier family 6 member 16
              4 of 15
              607972
                  SLC6A17; solute carrier family 6 member 17
                  4 of 15
                  610299
                    SLC6A1; solute carrier family 6 member 1
                    3 of 15
                    137165
                      SLC6A2; solute carrier family 6 member 2
                      3 of 15
                      163970
                      SLC6A3; solute carrier family 6 member 3
                      3 of 15
                      126455
                         
                        SLC6A4; solute carrier family 6 member 4
                        3 of 15
                        182138
                         
                        SLC6A5; solute carrier family 6 member 5
                        3 of 15
                        604159
                         
                        SLC6A6; solute carrier family 6 member 6
                        3 of 15
                        186854
                            SLC6A8; solute carrier family 6 member 8
                            3 of 15
                            300036
                            SLC6A11; solute carrier family 6 member 11
                            3 of 15
                            607952
                                SLC6A12; solute carrier family 6 member 12
                                3 of 15
                                603080
                                    SLC6A13; solute carrier family 6 member 13
                                    3 of 15
                                    615097
                                        SLC6A14; solute carrier family 6 member 14
                                        3 of 15
                                        300444
                                            Functional Complementation Data
                                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                            Interactions
                                            Summary of Physical Interactions
                                            esyN Network Diagram
                                            Show neighbor-neighbor interactions:
                                            Select Layout:
                                            Legend:
                                            Protein
                                            RNA
                                            Selected Interactor(s)
                                            Interactions Browser
                                            View in Interactions Browser
                                            Please see the Physical Interaction reports below for full details
                                            protein-protein
                                            Physical Interaction
                                            Assay
                                            References
                                            CG15279 - CG1532
                                            experimental knowledge based
                                            (Guruharsha et al., 2011)
                                            CG15279 - HIP-R
                                            experimental knowledge based
                                            (Guruharsha et al., 2011)
                                            Summary of Genetic Interactions
                                            esyN Network Diagram
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            External Data
                                            Linkouts
                                            DroID - A comprehensive database of gene and protein interactions.
                                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                            Pathways
                                            Signaling Pathways (FlyBase)
                                            Metabolic Pathways
                                            External Data
                                            Linkouts
                                            Genomic Location and Detailed Mapping Data
                                            Chromosome (arm)
                                            2L
                                            Recombination map
                                            2-50
                                            Cytogenetic map
                                            35B6-35B6
                                            Sequence location
                                            2L:14,844,993..14,851,749 [-]
                                            FlyBase Computed Cytological Location
                                            Cytogenetic map
                                            Evidence for location
                                            35B6-35B6
                                            Limits computationally determined from genome sequence between P{EP}elBEP2039&P{PZ}osprJ571 and P{lacW}Su(H)k07904
                                            Experimentally Determined Cytological Location
                                            Cytogenetic map
                                            Notes
                                            References
                                            Experimentally Determined Recombination Data
                                            Location

                                            2-50

                                            (FlyBase, 2016)

                                            2-47.5

                                            (Comeron et al., 2012)
                                            Left of (cM)
                                            Right of (cM)
                                            Notes
                                            Stocks and Reagents
                                            Stocks (6)
                                            Genomic Clones (19)
                                            cDNA Clones (18)
                                             

                                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                            cDNA clones, fully sequenced
                                            BDGP DGC clones
                                            Other clones
                                            Drosophila Genomics Resource Center cDNA clones

                                            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                            cDNA Clones, End Sequenced (ESTs)
                                            BDGP DGC clones
                                            Other clones
                                            RNAi and Array Information
                                            Linkouts
                                            DRSC - Results frm RNAi screens
                                            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                            Antibody Information
                                            Laboratory Generated Antibodies
                                             
                                            Commercially Available Antibodies
                                             
                                            Other Information
                                            Relationship to Other Genes
                                            Source for database identify of
                                            Source for database merge of

                                            Source for merge of: CG15279 anon-WO0149848.9

                                            (FlyBase, 1996-)
                                            Additional comments

                                            Source for merge of CG15279 anon-WO0149848.9 was sequence comparison ( date:051113 ).

                                            (FlyBase, 1996-)
                                            Other Comments
                                            Origin and Etymology
                                            Discoverer
                                            Etymology
                                            Identification
                                            External Crossreferences and Linkouts ( 45 )
                                            Sequence Crossreferences
                                            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                            Other crossreferences
                                            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                            DRscDB
                                            EMBL-EBI Single Cell Expression Atlas
                                            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                            Flygut - An atlas of the Drosophila adult midgut
                                            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                            InterPro - A database of protein families, domains and functional sites
                                            KEGG Genes - Molecular building blocks of life in the genomic space.
                                            MARRVEL_MODEL
                                            modMine - A data warehouse for the modENCODE project
                                            Linkouts
                                            DroID - A comprehensive database of gene and protein interactions.
                                            DRSC - Results frm RNAi screens
                                            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                            FlyMine - An integrated database for Drosophila genomics
                                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                            Synonyms and Secondary IDs (5)
                                            Datasets (0)
                                            Study focus (0)
                                            Experimental Role
                                            Project
                                            Project Type
                                            Title
                                            References (43)