FlyBase Allele Report: Dmel\GluRIIA[PV3]

General Information

Symbol

Dmel\GluRIIA^PV3

Species

D. melanogaster

Name

FlyBase ID

FBal0392519

Feature type

allele

Associated gene

Dmel\GluRIIA

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Han et al., 2023)

Mutagen

CRISPR/Cas9

(Han et al., 2023)

Progenitor genotype

Cytology

Description

Amino acid replacement: D277term.

(Han et al., 2023)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:5,556,442..5,556,442 [+]

Comment:

A 1bp deletion in GluRIIA leads to a frameshift and early translation termination.

(Chien and Dickman, 2023.12.14)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | larval stage

(Chen et al., 2024, Han et al., 2023)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage

(Han et al., 2023)

hypodermal muscle of A1-7 | larval stage

(Chen et al., 2024)

motor neuron | larval stage

(Han et al., 2023)

type Ib motor neuron | larval stage

(Han et al., 2023)

type Is motor neuron | larval stage

(Han et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

GluRIIA^PV3 has abnormal neurophysiology | larval stage phenotype, suppressible | partially by Scer\GAL4^VGlut1-OK371/VGlut1^UAS.cDa

(Han et al., 2023)

Other

Statement

Reference

Cbot\BoNT-C^LC.UAS.cHa, GluRIIA^PV3, Scer\GAL4^GMR27E09 has abnormal neurophysiology | larval stage phenotype

(Han et al., 2023)

Cbot\BoNT-C^LC.UAS.cHa, GluRIIA^PV3, Scer\GAL4^exex-Gal4 has abnormal neurophysiology | larval stage phenotype

(Han et al., 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

GluRIIA^PV3 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible | partially by Scer\GAL4^VGlut1-OK371/VGlut1^UAS.cDa

(Han et al., 2023)

GluRIIA^PV3 has motor neuron | larval stage phenotype, suppressible | partially by Scer\GAL4^VGlut1-OK371/VGlut1^UAS.cDa

(Han et al., 2023)

GluRIIA^PV3 has type Ib motor neuron | larval stage phenotype, suppressible | partially by Scer\GAL4^VGlut1-OK371/VGlut1^UAS.cDa

(Han et al., 2023)

GluRIIA^PV3 has type Is motor neuron | larval stage phenotype, suppressible | partially by Scer\GAL4^VGlut1-OK371/VGlut1^UAS.cDa

(Han et al., 2023)

Other

Statement

Reference

Cbot\BoNT-C^LC.UAS.cHa, GluRIIA^PV3, Scer\GAL4^GMR27E09 has embryonic/larval neuromuscular junction | larval stage phenotype

(Han et al., 2023)

Cbot\BoNT-C^LC.UAS.cHa, GluRIIA^PV3, Scer\GAL4^GMR27E09 has type Ib motor neuron | larval stage phenotype

(Han et al., 2023)

Cbot\BoNT-C^LC.UAS.cHa, GluRIIA^PV3, Scer\GAL4^exex-Gal4 has embryonic/larval neuromuscular junction | larval stage phenotype

(Han et al., 2023)

Cbot\BoNT-C^LC.UAS.cHa, GluRIIA^PV3, Scer\GAL4^exex-Gal4 has type Is motor neuron | larval stage phenotype

(Han et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

GluRIIA^PV3

(Qiu et al., 2025, Han et al., 2023)

GluRIIA^pv3

(Chen et al., 2026, Stark et al., 2025, Chen et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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