FlyBase Allele Report: Dmel\PVRAP[1]

General Information

Symbol

Dmel\PVRAP¹

Species

D. melanogaster

Name

FlyBase ID

FBal0392870

Feature type

allele

Associated gene

Dmel\PVRAP

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Martínez-Abarca Millán et al., 2023)

Mutagen

CRISPR/Cas9

(Martínez-Abarca Millán et al., 2023)

Progenitor genotype

Cytology

Description

Deletion of 2bp in exon 1 of PVRAP results in a frameshift and stop codon after amino acid 29.

(Martínez-Abarca Millán et al., 2023)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by Ras85D^V12.UAS

(Martínez-Abarca Millán et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | larval stage

(Martínez-Abarca Millán et al., 2023)

viable

(Martínez-Abarca Millán et al., 2023)

Phenotype Manifest In

wing disc

(Martínez-Abarca Millán et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

PVRAP¹ is an enhancer of hyperplasia | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

PVRAP¹ is an enhancer of abnormal cell shape | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

PVRAP¹ is an enhancer of increased cell growth rate | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

PVRAP¹ is an enhancer of increased cell death | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

NOT Enhancer of

Statement

Reference

PVRAP¹ is a non-enhancer of abnormal mitotic cell cycle | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

PVRAP¹ is a non-enhancer of abnormal cell migration | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

Suppressor of

Statement

Reference

PVRAP¹ is a suppressor of decreased occurrence of cell division | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

NOT Suppressor of

Statement

Reference

PVRAP¹ is a non-suppressor of abnormal mitotic cell cycle | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

PVRAP¹ is a non-suppressor of abnormal cell migration | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

Phenotype Manifest In

Enhancer of

Statement

Reference

PVRAP¹ is an enhancer of wing disc phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

PVRAP¹

(Martínez-Abarca Millán et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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