FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pbltumH.UASp.Tag:FLAG
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General Information
Symbol
Dmel\pbltumH.UASp.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0398828
Feature type
allele
Associated gene
Dmel\pbl
Associated Insertion(s)
Carried in Construct
P{UASp-pbl.tumH.FLAG}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Xu, 2021.6.9)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Xu, 2021.6.9)
Mutagen
in vitro construct
(Xu, 2021.6.9)
Progenitor genotype
Carried in construct
P{UASp-pbl.tumH.FLAG}
Cytology
Description

UASp sequences regulate expression of a mutated form of pbl that carries a T758P amino acid substitution. This change is equivalent to a T802P change in the human ECT2 gene (a variant identified in human cancers). The coding sequence is tagged with Tag:FLAG.

(Xu, 2021.6.9)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
pbl
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:7,897,133..7,897,133 [-]
Nucleotide change:

A7897133C

Amino acid change:

T758P | pbl-PA; T1216P | pbl-PB; T687P | pbl-PC; T1145P | pbl-PD; T805P | pbl-PE; T472P | pbl-PF

Reported amino acid change:

T758P

Comment:

Analogous mutation in human ECT2 implicated in cancer; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Xu, 2021.6.9)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Xu, 2021.6.9)
      ECT2:p.Thr833Pro
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      ECT2:p.Thr802Pro
      ECT2:p.Thr773Pro
      ECT2:p.Thr801Pro
      ECT2:p.Thr832Pro
      Associated human disease model(s)
        External database links
        COSMIC_gene: analysis?ln=ECT2
        Comments concerning this variant

        Disease model in flies has not been developed.

        (FlyBase curators, 2019-)
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        pbltumH.UASp.Tag:FLAG
        Name Synonyms
        Secondary FlyBase IDs
          References (2)