FlyBase Allele Report: Dmel\Amus[A-1-3]

General Information

Symbol

Dmel\Amus^A-1-3

Species

D. melanogaster

Name

FlyBase ID

FBal0398849

Feature type

allele

Associated gene

Dmel\Amus

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Peng et al., 2023)

Mutagen

CRISPR/Cas9

(Peng et al., 2023)

Progenitor genotype

Cytology

Description

10bp deletion within the Amus coding region. This results in a frameshift and premature stop codon after the 97th residue.

(Peng et al., 2023)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of second instar larval stage

(Peng et al., 2023)

lethal - all die before end of second instar larval stage (with Df(3R)BSC47)

(Peng et al., 2023)

sterile (with Amus^1-1)

(Peng et al., 2023)

sterile (with Amus^1-1), with Amus^Y84A.gDNA

(Peng et al., 2023)

sterile (with Df(3R)BSC47), with Amus^Y84A.gDNA

(Peng et al., 2023)

viable (with Amus^1-1)

(Peng et al., 2023)

Phenotype Manifest In

egg chamber (with Amus^1-1)

(Peng et al., 2023)

testis (with Amus^1-1)

(Peng et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Amus::Hsap\MEPCE^UAS.cPa, Amus^A-1-3, Scer\GAL4^Act5C.PI has lethal - all die during P-stage phenotype

(Peng et al., 2023)

Amus::Hsap\MEPCE^UAS.cPa, Amus^A-1-3/Df(3R)BSC47, Scer\GAL4^Act5C.PI has lethal - all die during P-stage phenotype

(Peng et al., 2023)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Amus^A-1-3 is rescued by Amus^UAS.cPa/Scer\GAL4^Act5C.PI

(Peng et al., 2023)

Amus^A-1-3/Df(3R)BSC47 is rescued by Amus^UAS.cPa/Scer\GAL4^Act5C.PI

(Peng et al., 2023)

Amus^A-1-3/Df(3R)BSC47 is rescued by Amus^Y84A.gDNA

(Peng et al., 2023)

Not rescued by

Amus^A-1-3 is not rescued by Amus^K201A.gDNA

(Peng et al., 2023)

Amus^A-1-3 is not rescued by Amus^Y83F.gDNA

(Peng et al., 2023)

Amus^A-1-3/Df(3R)BSC47 is not rescued by Amus^K201A.gDNA

(Peng et al., 2023)

Amus^A-1-3/Df(3R)BSC47 is not rescued by Amus^Y83F.gDNA

(Peng et al., 2023)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

607811

w^*; Amus^A-1-3/TM2

607809

w^*; PBac{Amus.gDNA.GFP}VK00005 Amus^A-1-3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Amus^A-1-3

amus^A-1-3

(Peng et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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