FB2026_02 , released June 18, 2026
Allele: Dmel\RpS7K2R
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General Information
Symbol
Dmel\RpS7K2R
Species
D. melanogaster
Name
FlyBase ID
FBal0405269
Feature type
allele
Associated gene
Dmel\RpS7
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Villa et al., 2024)
gene targeting by homologous recombination
(Villa et al., 2024)
Progenitor genotype
Cytology
Description

Amino acid replacement: K83R.

(Villa et al., 2024)

Amino acid replacement: K84R.

(Villa et al., 2024)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:30,208,346..30,208,346 [-]
Nucleotide change:

A30208346G

Reported nucleotide change:

A?G

Amino acid change:

K83R | RpS7-PA; K83R | RpS7-PC; K83R | RpS7-PD; K83R | RpS7-PE

Reported amino acid change:

K83R

Comment:

Two adjacent residues are mutated from Lys to Arg in the RpS7 coding region. This is the site of the first substitution. A silent substitution (G to C) was also introduced in codon L81.

(Villa et al., 2024)
point_mutation
3R:30,208,343..30,208,343 [-]
Nucleotide change:

A30208343G

Reported nucleotide change:

A?G

Amino acid change:

K84R | RpS7-PA; K84R | RpS7-PC; K84R | RpS7-PD; K84R | RpS7-PE

Reported amino acid change:

K84R

Comment:

Two adjacent residues are mutated from Lys to Arg in the RpS7 coding region. This is the site of the second substitution. A silent substitution (G to C) was also introduced in codon L81.

(Villa et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      RpS7K2R has chemical sensitive | adult stage phenotype, enhanceable by Otud6C183A

      (Villa et al., 2024)

      RpS7K2R has increased mortality | adult stage phenotype, enhanceable by Otud6C183A

      (Villa et al., 2024)
      NOT Enhancer of
      Statement
      Reference

      RpS7K2R/RpS7K2R is a non-enhancer of chemical sensitive | adult stage phenotype of Otud6C183A

      (Villa et al., 2024)

      RpS7K2R/RpS7K2R is a non-enhancer of increased mortality | adult stage phenotype of Otud6C183A

      (Villa et al., 2024)
      NOT Suppressor of
      Statement
      Reference

      RpS7K2R/RpS7K2R is a non-suppressor of chemical sensitive | adult stage phenotype of Otud6C183A

      (Villa et al., 2024)

      RpS7K2R/RpS7K2R is a non-suppressor of increased mortality | adult stage phenotype of Otud6C183A

      (Villa et al., 2024)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RPS7K2R
      (Villa et al., 2024)
      RpS7K2R
      Name Synonyms
      Secondary FlyBase IDs
        References (1)