FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mettl1KO1
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General Information
Symbol
Dmel\Mettl1KO1
Species
D. melanogaster
Name
FlyBase ID
FBal0405660
Feature type
allele
Associated gene
Dmel\Mettl1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Kaneko et al., 2024)
Mutagen
CRISPR/Cas9
(Kaneko et al., 2024)
Progenitor genotype
Cytology
Description

1bp deletion in the N-terminal part of the Mettl1 transcription unit; results in a frameshift.

(Kaneko et al., 2024)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:2,075,569..2,075,569 [-]
Comment:

A 1bp deletion in the N-terminal part of the Mettl1 transcription unit results in a frameshift and early translation termination after the addition of 5 novel amino acids.

(Kaneko et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Mettl1KO1 has male semi-sterile phenotype, suppressible | partially by Scer\GAL4Act5C.PU/eEF1α1UAS.cKb

      (Kaneko et al., 2024)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Mettl1KO1 is rescued by Mettl1+tKa

      (Kaneko et al., 2024)

      Mettl1KO1 is rescued by Mettl1Tag:FLAG

      (Kaneko et al., 2024)

      Mettl1KO1 is rescued by Mettl1nanos.PK

      (Kaneko et al., 2024)
      Not rescued by

      Mettl1KO1 is not rescued by Mettl1Cd

      (Kaneko et al., 2024)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mettl1KO1
      (Kaneko et al., 2024)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)