FlyBase Allele Report: Dmel\CycC[TH00504.N]

FB2026_02 , released June 18, 2026

FB2026_02 , released June 18, 2026

Allele: Dmel\CycC^TH00504.N

General Information

Symbol

Dmel\CycC^TH00504.N

Species

D. melanogaster

Name

FlyBase ID

FBal0406669

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Transgenic product class

(Li et al., 2024)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Li et al., 2024)

Mutagen

in vitro construct

(Li et al., 2024)

Progenitor genotype

Carried in construct

Cytology

Description

UAS regulatory sequences plus the Drosophila Synthetic Core Promoter (DSCP) (from the pNP vector) regulate expression of two shRNAs; the first targets CycC (this hairpin contains an inverted repeat of CAAGGTGTTCCTGTTGATCGA) and the second targets Cdk8 (this hairpin contains an inverted repeat of CAAGGTGTTCCTGTTGATCGA).

(Li et al., 2024)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Cdk8^TH00504.N, CycC^TH00504.N, Scer\GAL4^ap-md544 has visible | adult stage phenotype

(Li et al., 2024)

Cdk8^TH00504.N, CycC^TH00504.N, Scer\GAL4^ap-md544 has increased occurrence of cell division | larval stage phenotype

(Li et al., 2024)

Cdk8^TH00504.N, CycC^TH00504.N, Scer\GAL4^en.PU has abnormal size | larval stage phenotype

(Li et al., 2024)

Cdk8^TH00504.N, CycC^TH00504.N, Scer\GAL4^nub-AC-62 has abnormal mitotic cell cycle | larval stage phenotype

(Li et al., 2024)

Phenotype Manifest In

Other

Statement

Reference

Cdk8^TH00504.N, CycC^TH00504.N, Scer\GAL4^ap-md544 has wing phenotype

(Li et al., 2024)

Cdk8^TH00504.N, CycC^TH00504.N, Scer\GAL4^ap-md544 has wing disc dorsal compartment | larval stage phenotype

(Li et al., 2024)

Cdk8^TH00504.N, CycC^TH00504.N, Scer\GAL4^en.PU has wing disc | larval stage phenotype

(Li et al., 2024)

Cdk8^TH00504.N, CycC^TH00504.N, Scer\GAL4^nub-AC-62 has wing disc | larval stage phenotype

(Li et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

606847

y¹ v¹; P{TH00504.N}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CycC^TH00504.N

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections