FB2026_02 , released June 18, 2026
Allele: Dmel\ptch7-7
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General Information
Symbol
Dmel\ptch7-7
Species
D. melanogaster
Name
FlyBase ID
FBal0406826
Feature type
allele
Associated gene
Dmel\ptch
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Chen et al., 2024)
Mutagen
CRISPR/Cas9
(Chen et al., 2024)
Progenitor genotype
Cytology
Description

An insertion of 9bp accompanied by a deletion of 4bp in ptch (revision of data in FBrf0261184).

(Rong, 2025.2.10)

Deletion plus insertion in ptch, generating a frameshift mutation in the C-terminal region that potentially encodes a truncated protein.

(Chen et al., 2024)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:10,028,093..10,028,096 [+]
Comment:

A 4bp deletion in ptch accompanied by a 9bp insertion (GAAACTAAA).

Inserted_sequence:

GAAACTAAA

(Rong, 2025.2.10)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      ptch7-7/ptch12-2 is rescued by ptch+5.8

      (Chen et al., 2024)
      Not rescued by

      ptch7-7/ptch12-2 is not rescued by ptcham.EGFP

      (Chen et al., 2024)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ptch7-7
      (Chen et al., 2024)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)