UASt sequences regulate expression of N in which a. the N-terminal EGF repeat containing part of the extracellular domain has been replaced by sequence encoding a signal peptide and Tag:LBD(FSHR), b. the juxtamembrane NRR (negative regulatory region) has been replaced with the wild-type A2 domain (a force sensor) of the Homo sapiens VWF gene (HGNC:12726) and c. the cytosolic domain of N has been replaced with sequence encoding the lexA::VP16 driver. The coding sequence is tagged with mCherry just upstream of the A2 domain. A single FRT site is present in between the UASt and coding sequences. The protein encodes a synthetic receptor that is expressed at the cell surface. Receptor activation occurs at the interface between cells expressing the receptor and those expressing a protein that includes Tag:LIG(FSHb) (in the presence of a source of Tag:LIG(CGA))), resulting in cleavage which allows the lexA::VP16 driver to translocate to the nucleus.