FlyBase Allele Report: Dmel\Hrs[RNAi.UAS.cUa]

General Information

Symbol

Dmel\Hrs^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0407445

Feature type

allele

Associated gene

Dmel\Hrs

Associated Insertion(s)

Carried in Construct

P{UAS-Hrs.RNAi.U}

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Hrs.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi construct targeting Hrs.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hrs

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^repo.PU

(Yuva-Aydemir et al., 2011)

lethal, with Scer\GAL4^da.G32

(Yuva-Aydemir et al., 2011)

visible, with Scer\GAL4^Bx-MS1096

(Fan et al., 2013)

Phenotype Manifest In

eye disc, with Scer\GAL4^repo.PU

(Yuva-Aydemir et al., 2011)

glial cell, with Scer\GAL4^repo.PU

(Yuva-Aydemir et al., 2011)

wing, with Scer\GAL4^Bx-MS1096

(Fan et al., 2013)

Detailed Description

Statement

Reference

Expression of Hrs^dsRNA.cUa in the wing under the control of Scer\GAL4^C-765 results in wings similar to wild-type.

(Fan et al., 2013)

Expression of Hrs^VDRC.cUa under the control of Scer\GAL4^repo.PU at 29[o]C results in fewer glial cells in the eye disc than normal.

(Yuva-Aydemir et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hrs^RNAi.UAS.cUa, Scer\GAL4^C-765 is an enhancer of visible phenotype of Scer\GAL4^C-765, smo^PKA12.UAS

(Fan et al., 2013)

Phenotype Manifest In

Enhancer of

Statement

Reference

Hrs^RNAi.UAS.cUa, Scer\GAL4^C-765 is an enhancer of wing vein L3 phenotype of Scer\GAL4^C-765, smo^PKA12.UAS

(Fan et al., 2013)

Hrs^RNAi.UAS.cUa, Scer\GAL4^C-765 is an enhancer of wing vein L4 phenotype of Scer\GAL4^C-765, smo^PKA12.UAS

(Fan et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Hrs^dsRNA.cUa with smo^{PKA12.Scer\UAS} under the control of Scer\GAL4^C-765 results in narrowing and further fusion between wing veins L3 and L4.

(Fan et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Hrs^RNAi.UAS.cUa

Hrs^VDRC.cUa

Hrs^{dsRNA.UAS.cUa}

Hrs^dsRNA.cUa

hrs_dsRNA

(Yuva-Aydemir et al., 2011)

Name Synonyms

Secondary FlyBase IDs

FBal0291776
FBal0263454

References (5)

Report Sections

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