FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tssk2KO
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General Information
Symbol
Dmel\Tssk2KO
Species
D. melanogaster
Name
FlyBase ID
FBal0408365
Feature type
allele
Associated gene
Dmel\Tssk2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Peng et al., 2025)
Mutagen
CRISPR/Cas9
(Peng et al., 2025)
Progenitor genotype
Cytology
Description

Knockout at the Tssk2 locus - a premature stop codon eliminates the kinase catalytic domain of Tssk2 protein, and transcript levels are significantly reduced.

(Peng et al., 2025)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:6,131,220..6,131,221 [+]
Comment:

A 2bp deletion ins Tssk2 leads to a frameshift which eliminates the kinase catalytic domain.

(Peng et al., 2025)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Tssk2KO has male semi-sterile phenotype, suppressible by Hsap\TSSK4+tPa

      (Peng et al., 2025)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Tssk2KO has spermatozoon phenotype, suppressible by Hsap\TSSK4+tPa

      (Peng et al., 2025)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Tssk2KO is rescued by Tssk2+tPa

      (Peng et al., 2025)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Tssk2KO
      Name Synonyms
      Secondary FlyBase IDs
        References (1)