FlyBase Allele Report: Hsap\NPHS1[UAS.cWb]

FB2026_02 , released June 18, 2026

FB2026_02 , released June 18, 2026

Allele: Hsap\NPHS1^UAS.cWb

General Information

Symbol

Hsap\NPHS1^UAS.cWb

Species

H. sapiens

Name

UAS construct b of Wolff

FlyBase ID

FBal0409310

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

M{UAS-hNPHS1.Wb}

Key Links

Transgenic product class

(Wolff et al., 2025)

(Wolff et al., 2025)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Wolff et al., 2025)

(Wolff et al., 2025)

Mutagen

in vitro construct

(Wolff et al., 2025)

Progenitor genotype

Carried in construct

M{UAS-hNPHS1.Wb}

Cytology

Description

UAS regulatory sequences drive expression of wild-type Hsap\NPHS1 cDNA (GenBank BC156935.1).

(Wolff et al., 2025)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^Ugt36A1.PK

(Wolff et al., 2025)

Phenotype Manifest In

filamentous actin, with Scer\GAL4^Ugt36A1.PK

(Wolff et al., 2025)

nephrocyte, with Scer\GAL4^Ugt36A1.PK

(Wolff et al., 2025)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\NPHS1^UAS.cWb, Scer\GAL4^Ugt36A1.PK has increased cell death phenotype, suppressible by sns^HMC05745, Scer\GAL4^Ugt36A1.PK

(Wolff et al., 2025)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Hsap\NPHS1^UAS.cWb, Scer\GAL4^Ugt36A1.PK is a non-suppressor of nephrocyte phenotype of Scer\GAL4^Ugt36A1.PK, sns^HMC05745

(Wolff et al., 2025)

Hsap\NPHS1^UAS.cWb, Scer\GAL4^Ugt36A1.PK is a non-suppressor of filamentous actin phenotype of Scer\GAL4^Ugt36A1.PK, sns^HMC05745

(Wolff et al., 2025)

Other

Statement

Reference

Hsap\NPHS1^UAS.cWb, Scer\GAL4^Ugt36A1.PK, sns^HMC05745 has nephrocyte phenotype

(Wolff et al., 2025)

Hsap\NPHS1^UAS.cWb, Mmus\Kirrel^UAS.Tag:V5, Scer\GAL4^Ugt36A1.PK, sns^HMC05745 has nephrocyte phenotype

(Wolff et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\NPHS1^UAS.cWb

Name Synonyms

UAS construct b of Wolff

Secondary FlyBase IDs

References (1)

Report Sections