FB2026_02 , released June 18, 2026
Allele: Dmel\Rcc1hRCC1.G43S
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General Information
Symbol
Dmel\Rcc1hRCC1.G43S
Species
D. melanogaster
Name
FlyBase ID
FBal0409879
Feature type
allele
Associated gene
Dmel\Rcc1
Associated Insertion(s)
TI{TI}Rcc1hRCC1.G43S
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Harkness et al., 2025)
gene targeting by homologous recombination
(Harkness et al., 2025)
Progenitor genotype
Associated Insertion(s)
TI{TI}Rcc1hRCC1.G43S
Cytology
Description

The entire coding sequence of the Rcc1 locus has been deleted and replaced with sequence that encodes the Hsap\RCC1 coding sequence that has been mutated to carry a G43S amino acid substitution (a putative pathogenic variant identified in patients with acute-onset axonal neuropathy following infection), and which is tagged at the N-terminal end with mScarlet-I (allowing expression of the tagged Hsap\RCC1 protein under the control of Rcc1 regulatory sequences). A Avic\GFP3xP3.cUa marker has also been inserted, downstream of the Hsap\RCC1 coding sequence.

(Harkness et al., 2025)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Rcc1hRCC1.G43S
      Name Synonyms
      Secondary FlyBase IDs
        References (1)