FlyBase Allele Report: Dmel\Tmbim5[KO]

General Information

Symbol

Dmel\Tmbim5^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0410149

Feature type

allele

Associated gene

Dmel\Tmbim5

Associated Insertion(s)

TI{TI}Tmbim5^KO

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Zhang et al., 2025)

gene targeting by homologous recombination

(Zhang et al., 2025)

Progenitor genotype

Associated Insertion(s)

TI{TI}Tmbim5^KO

Cytology

Description

An attP-Disc\RFP^3xP3.cUa-loxP cassette replaces a 1,460bp fragment (-36 nt to +1,424 nt from the ATG) of Tmbim5.

(Zhang et al., 2025)

Allele components

Component

Use(s)

Also carries

attP

integrase target site

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage

(Zhang et al., 2025)

decreased rate of adult locomotory behavior

(Zhang et al., 2025)

short lived

(Zhang et al., 2025)

viable

(Zhang et al., 2025)

visible | adult stage

(Zhang et al., 2025)

Phenotype Manifest In

flight muscle | adult stage

(Zhang et al., 2025)

mitochondrial crista | adult stage

(Zhang et al., 2025)

mitochondrion | adult stage

(Zhang et al., 2025)

wing

(Zhang et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Tmbim5^KO has short lived phenotype, enhanceable by MCU¹

(Zhang et al., 2025)

Tmbim5^KO has short lived phenotype, enhanceable by EMRE¹/EMRE¹

(Zhang et al., 2025)

Tmbim5^KO has short lived phenotype, enhanceable by MICU3²⁷/MICU3²⁷

(Zhang et al., 2025)

Suppressed by

Statement

Reference

Tmbim5^KO has decreased rate of adult locomotory behavior phenotype, suppressible by MICU1³²

(Zhang et al., 2025)

Tmbim5^KO has decreased rate of adult locomotory behavior phenotype, suppressible by Scer\GAL4^da.PU/MICU1^HMS02302

(Zhang et al., 2025)

Tmbim5^KO has abnormal size | adult stage phenotype, suppressible by MICU1³²

(Zhang et al., 2025)

Other

Statement

Reference

MICU1³², Tmbim5^KO has long lived phenotype

(Zhang et al., 2025)

Phenotype Manifest In

Suppressed by

Statement

Reference

Tmbim5^KO has mitochondrion | adult stage phenotype, suppressible by MICU1³²

(Zhang et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Tmbim5^KO is rescued by Tmbim5^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^da.PU

(Zhang et al., 2025)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Tmbim5 KO

(Zhang et al., 2025)

Tmbim5^KO

dT5-KO

(Zhang et al., 2025)

dTmbim5-KO

(Zhang et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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