FB2026_03 , released September 17, 2026
Allele: Dmel\Hel25EG33C.UAS
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General Information
Symbol
Dmel\Hel25EG33C.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0414145
Feature type
allele
Associated gene
Dmel\Hel25E
Associated Insertion(s)
Carried in Construct
PBac{UAS-Hel25E.G33C}
Key Links
Transgenic product class
missense_variant
(Booth et al., 2025)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Booth et al., 2025)
Mutagen
in vitro construct
(Booth et al., 2025)
Progenitor genotype
Carried in construct
PBac{UAS-Hel25E.G33C}
Cytology
Description

UAS sequences regulate expression of Hel25E that has been mutated to carry a G33C amino acid substitution. This change is equivalent to a variant in the orthologous human DDX39B gene that has been identified in a patient with a neurodevelopmental disorder.

(Booth et al., 2025)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hel25E
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Booth et al., 2025)
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Hel25EG33C.UAS fails to rescue Hel25ECR70488-KO-kG4/Df(2L)BSC167

      (Booth et al., 2025)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hel25EG33C.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)