Gene Group: CLASS B GPCRs, SUBFAMILY B2

General Information

Name

CLASS B GPCRs, SUBFAMILY B2

Species

D. melanogaster

Symbol

GPCR-B2

FlyBase ID

FBgg0000049

Date last reviewed

2023-06-30

Number of members

Description

Class B2 subfamily GPCRs/Adhesion GPCRs are characterized by a long extracellular N-terminal domain and a GPCR proteolytic site (GPS), which is located within a conserved sixty residue domain N-terminally to the first transmembrane domain. During biosynthesis, auto-proteolytic cleavage results in the covalent separation of the polypeptide between the N-terminal extracellular domain and the transmembrane/intracellular C-terminal portion. However, GCPR retains it structural integrity by non-covalent interactions between the two polypeptides. (Adapted from FBrf0147071, FBrf0221117 and PMID:33497605).

Notes on Group

stan is also a member of the CADHERINS gene group. FBrf0147071 classify it as a Family B GPCR. This agrees with the HGNC gene family classification and is the grouping adopted here. FBrf0221117 use a slightly different classification system and classes stan as an atypical GPCR.

Source Material

The CLASS B GPCRs, SUBFAMILY B2 Gene Group has been compiled using the following publication(s): Vieira Contreras et al., 2024, Scholz et al., 2023, Hanlon and Andrew, 2015, Li et al., 2013, Vogel et al., 2013, and Harmar, 2001 .

Key Gene Ontology (GO) terms

Molecular Function

G protein-coupled receptor activity

Biological Process

G protein-coupled receptor signaling pathway

Cellular Component

plasma membrane

Related Gene Groups

Parent group(s)

CLASS B GPCRs

Members (5)

For all members: