FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: UCH DEUBIQUITINASES
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General Information
Name
UCH DEUBIQUITINASES
Species
D. melanogaster
Symbol
UCH-DUB
FlyBase ID
FBgg0000139
Date last reviewed
2020-06-08
Number of members
4
Description
Description
The ubiquitin C-terminal hydrolase (UCH) sub-family of deubiquitinases are cysteine proteases and that catalyze the removal of ubiquitin from ubiquitin chains and ubiquitinated proteins. UCH deubiquitinases belong to MEROPS family C12. (Adapted from PMID:19626045).
Notes on Group
Source Material
The UCH DEUBIQUITINASES Gene Group has been compiled using the following publication(s): Páhi et al., 2022, Badmos et al., 2021, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
cysteine-type deubiquitinase activity
Biological Process
protein deubiquitination
Cellular Component
Enzymatic activity
Enzyme name (EC)
ubiquitinyl hydrolase 1 (3.4.19.12)
Related Gene Groups
Parent group(s)
CYSTEINE-TYPE DEUBIQUITINASES
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)

[MEROPS Family C12](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=c12)

Synonyms and Secondary IDs
Synonym(s)
UCH-DUB
ubiquitin C-terminal hydrolase
Uch
UBIQUITIN C-TERMINAL HYDROLASES (DEUBIQUITINASES)
UCH DEUBIQUITINASES
Secondary FlyBase ID(s)
References (8)