Complex: COP9 SIGNALOSOME

General Information

Name

COP9 SIGNALOSOME

Species

D. melanogaster

Symbol

COP9

FlyBase ID

FBgg0000152

Date last reviewed

2024-01-25

Number of members

Description

The COP9 signalosome is an eight-subunit complex that is structurally and evolutionarily related to the 19S lid of the 26S proteasome. The COP9 signalosome plays a central role in the regulation of the E3-cullin RING ubiquitin ligases, deNEDDylating the cullin subunit via the isopeptidase activity of the CNS5 subunit. (Adapted from FBrf0225508 and FBrf0225509).

Notes on Group

COP9 is an acronym from Constitutive photomorphogenesis 9, derived from its identification in Arabidopsis as as a repressor of photomorphogenesis.

There are two alternative isoforms of the CSN1 subunit. High-throughput expression studies indicate that CSN1b is more ubiquitously expressed and CSN1a is testis-specific.

Source Material

The COP9 SIGNALOSOME Gene Group has been compiled using the following publication(s): Wei and Deng, 2003 and Freilich et al., 1999 .

Key Gene Ontology (GO) terms

Molecular Function

deNEDDylase activity

Biological Process

protein deneddylation

Cellular Component

COP9 signalosome

Related Gene Groups

Parent group(s)

COP9 SIGNALOSOME COMPLEXES