Gene Group: PROTEASOME SUBUNITS

General Information

Name

PROTEASOME SUBUNITS

Species

D. melanogaster

Symbol

PSM

FlyBase ID

FBgg0000208

Date last reviewed

2023-04-03

Number of members

Description

The 26S proteasome degrades polyubiquitinated proteins in the cytoplasm and nucleus. It is formed from a cylindrical catalytic core 20S proteasome capped at each end by a regulatory 19S particle. The 19S regulatory particle recognizes, unfolds, and translocates ubiquitinated proteins into the catalytic core particle in an ATP-dependent manner. (Adapted from FBrf0215459).

Notes on Group

The PROTEASOME SUBUNITS gene group includes testes-specific proteasome genes that have arisen via gene duplication.

At least two different nomenclature systems are in use for 26S proteasome subunits. The proteasome genes in FlyBase have been standardized according to FBrf0215459 and largely mirror community usage. This system is also used in yeast. Vertebrate proteasome subunit nomenclature follows a slightly different system - for orthology, check sequence similarity rather than relying names.

Source Material

The PROTEASOME SUBUNITS Gene Group has been compiled using the following publication(s): Crosby et al., 2013.1.30, Belote and Zhong, 2009, Ma et al., 2002, and Rawlings and Barrett, 1996- .

Key Gene Ontology (GO) terms

Molecular Function

threonine-type endopeptidase activity

Biological Process

proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component

proteasome complex

Enzymatic activity

Enzyme name (EC)

3.4.25.-

Related Gene Groups

Component group(s)