FB2026_02 , released June 18, 2026
Gene Group: PROTEIN KINASE C FAMILY
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General Information
Name
PROTEIN KINASE C FAMILY
Species
D. melanogaster
Symbol
PKC
FlyBase ID
FBgg0000246
Date last reviewed
2025-01-07
Number of members
5
Description
Description
The Protein Kinase C (PKC) family are serine/threonine kinases which can be divided into three subfamilies - classical, novel and atypical, depending on their mode of activation. PKCs are regulated by auto-inhibition through a pseudosubstrate site located in the regulatory domain. (Adapted from PMID:20094051 and FBrf0152086).
Notes on Group
Source Material
The PROTEIN KINASE C FAMILY Gene Group has been compiled using the following publication(s): Sopko et al., 2014, Manning et al., 2002, Shieh et al., 2002, and Morrison et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
protein serine/threonine kinase activity
Biological Process
Cellular Component
Enzymatic activity
Enzyme name (EC)
2.7.11.-
Related Gene Groups
Parent group(s)
AGC-KINASES
Component group(s)
ATYPICAL PROTEIN KINASE C SUBFAMILY
CLASSICAL PROTEIN KINASE C SUBFAMILY
NOVEL PROTEIN KINASE C SUBFAMILY
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
PKC
PROTEIN KINASE C FAMILY
PKCs
Secondary FlyBase ID(s)
References (5)