Complex: POLYCOMB REPRESSIVE COMPLEX 1, PSC VARIANT

General Information

Name

POLYCOMB REPRESSIVE COMPLEX 1, PSC VARIANT

Species

D. melanogaster

Symbol

PRC1

FlyBase ID

FBgg0000273

Date last reviewed

2023-08-08

Number of members

Description

The Polycomb repressive complex 1 (PRC1) is a Polycomb group complex. It binds to histone H3K27me3 (histone H3 K27 methylation is catalyzed by PRC2) and monoubiquitinates H2A on K119. This leads to chromatin compaction, RNA polymerase II stalling and gene silencing. (Adapted from FBrf0179742 and FBrf0228921).

Notes on Group

This list does not include Scm which is less strongly associated with PRC1 (FBrf0228921). PRC1 may interact with various other factors, giving rise to multiple PRC1-like complexes with differing activities (FBrf0220020, FBrf0228971 and FBrf0232732).

Source Material

The POLYCOMB REPRESSIVE COMPLEX 1, PSC VARIANT Gene Group has been compiled using the following publication(s): Piunti and Shilatifard, 2016, Grossniklaus and Paro, 2014, and Lanzuolo and Orlando, 2012 .

Key Gene Ontology (GO) terms

Molecular Function

histone H2AK119 ubiquitin ligase activity

Biological Process

heterochromatin formation

Cellular Component

PRC1 complex

Related Gene Groups

Parent group(s)

CHROMATIN MODIFYING COMPLEXES

POLYCOMB GROUP COMPLEXES

Members (5)