FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Complex: TRANSCRIPTION FACTOR II H - CORE COMPLEX
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General Information
Name
TRANSCRIPTION FACTOR II H - CORE COMPLEX
Species
D. melanogaster
Symbol
TFIIH-C
FlyBase ID
FBgg0000357
Date last reviewed
2022-02-17
Number of members
7
Description
Description
The general transcription factor complex Transcription factor II H (TFIIH) core complex, is a subcomplex of the TFIIH holoenzyme required in RNA pol II transcription with an ATP-dependent DNA helicase activity required for promoter DNA opening. TFIIH also functions in nucleotide excision repair (NER). After complex loading and the verification step of NER, the cyclin-dependent protein kinase-activating kinase (CAK) subcomplex dissociates and the TFIIH core complex functions independently. (Adapted from PMID:25693126, PMID:21592869 and PMID:30798933).
Notes on Group
Source Material
The TRANSCRIPTION FACTOR II H - CORE COMPLEX Gene Group has been compiled using the following publication(s): Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, and Aoyagi and Wassarman, 2000 .
Key Gene Ontology (GO) terms
Molecular Function
RNA polymerase II general transcription initiation factor activity
Biological Process
transcription initiation at RNA polymerase II promoter
Cellular Component
core TFIIH complex portion of holo TFIIH complex
Related Gene Groups
Parent group(s)
TRANSCRIPTION FACTOR II H HOLOENZYME
Members (7)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
TFIIH-C
TRANSCRIPTION FACTOR II H - CORE COMPLEX
TF-IIH core
Secondary FlyBase ID(s)
References (5)