FB2026_03 , released September 17, 2026
Gene Group: INTRACELLULAR CHLORIDE CHANNEL FAMILY
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General Information
Name
INTRACELLULAR CHLORIDE CHANNEL FAMILY
Species
D. melanogaster
Symbol
CLIC
FlyBase ID
FBgg0000566
Date last reviewed
2025-01-21
Number of members
1
Description
Description
The intracellular chloride channel (CLIC) family can exist as both monomeric soluble proteins and integral membrane proteins in organelles where they function as chloride-selective ion channels. CLIC proteins are characterised by the presence of a 240 residue CLIC module, whose structure belongs to the GST-fold superfamily. (Adapted from FBrf0204349 and FBrf0232068).
Notes on Group

The INTRACELLULAR CHLORIDE CHANNEL SUBUNITS gene group contains only one member.

It should be noted that the INTRACELLULAR CHLORIDE CHANNEL SUBUNITS represent a group related by sequence/structural features. There are other chloride channels that mediate the transmembrane transport of chloride ions in intracellular compartments within subgroups of the CHLORIDE CHANNEL SUBUNITS gene group.

Source Material
The INTRACELLULAR CHLORIDE CHANNEL FAMILY Gene Group has been compiled using the following publication(s): Chintapalli et al., 2013, Bhandari et al., 2012, Littler et al., 2010, and Littler et al., 2008 .
Key Gene Ontology (GO) terms
Molecular Function
chloride channel activity
Biological Process
chloride transmembrane transport
Cellular Component
organelle membrane
Related Gene Groups
Parent group(s)
CHLORIDE CHANNEL SUBUNITS
Members (1)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
CLIC
INTRACELLULAR CHLORIDE CHANNEL FAMILY
INTRACELLULAR CHLORIDE CHANNEL SUBUNITS
Secondary FlyBase ID(s)
References (5)