FB2026_02 , released June 18, 2026
Gene Group: RUNT DOMAIN TRANSCRIPTION FACTORS
Open Close
General Information
Name
RUNT DOMAIN TRANSCRIPTION FACTORS
Species
D. melanogaster
Symbol
RUNT
FlyBase ID
FBgg0000766
Date last reviewed
2017-07-28
Number of members
4
Description
Description
Runt-domain (RD) transcription factors are sequence-specific DNA binding proteins that regulate transcription. These proteins are characterized by a Runt domain of 128 amino acids that mediates DNA binding and heterodimerization with a non-DNA binding β-subunit to form the Core Binding Factor transcription factor complex. (Adapted from FBrf0206845 and FBrf0138356).
Notes on Group

The RUNT DOMAIN TRANSCRIPTION FACTORS heterodimerize with non-DNA binding β-subunits Bro or Bgb, which are CORE BINDING FACTOR BETA members, to form the Core Binding Factor transcription factor complex (FBrf0138356).

Source Material
The RUNT DOMAIN TRANSCRIPTION FACTORS Gene Group has been compiled using the following publication(s): Bao and Friedrich, 2008 and Duncan et al., 2008 .
Key Gene Ontology (GO) terms
Molecular Function
DNA-binding transcription factor activity
transcription cis-regulatory region binding
Biological Process
regulation of DNA-templated transcription
Cellular Component
nucleus
Related Gene Groups
Parent group(s)
CORE BINDING FACTOR
IMMUNOGLOBULIN FOLD TRANSCRIPTION FACTORS
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
RUNT
RUNT DOMAIN TRANSCRIPTION FACTORS
Secondary FlyBase ID(s)
References (3)