Gene Group: ALPHA-MANNOSIDASES

General Information

Name

ALPHA-MANNOSIDASES

Species

D. melanogaster

Symbol

A-MAN

FlyBase ID

FBgg0000859

Date last reviewed

2018-01-30

Number of members

Description

Alpha-mannosidases catalyze the cleavage of terminal mannose linkages from N-linked oligosaccharides (Man(9)GlcNAc(2)). Class I α-mannosidases (GH47) are involved in the processing and quality control of N-glycans, and Class II α-mannosidases (GH38) are involved in the building and catabolism of N-glycans. (Adapted from PMID:17116466).

Notes on Group

Source Material

The ALPHA-MANNOSIDASES Gene Group has been compiled using the following publication(s): Jang et al., 2015, Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013, and Mortimer et al., 2012 .

Key Gene Ontology (GO) terms

Molecular Function

alpha-mannosidase activity

Biological Process

N-glycan processing

Cellular Component

Enzymatic activity

Enzyme name (EC)

alpha-mannosidase (3.2.1.24)

Related Gene Groups

Parent group(s)

MANNOSIDASES