Complex: SCF-SLMB UBIQUITIN LIGASE COMPLEX

General Information

Name

SCF-SLMB UBIQUITIN LIGASE COMPLEX

Species

D. melanogaster

Symbol

SCF-SLMB

FlyBase ID

FBgg0000894

Date last reviewed

2023-08-08

Number of members

Description

SCF-slmb ubiquitin ligase complex ubiquitinates proteins, targeting them for degradation by the proteasome. (FBrf0217546).

Notes on Group

The SCF-slmb ubiquitin ligase complex has been shown to play a key role in the negative regulation of the canonical Wnt, Hedgehog (FBrf0214241) and insulin-like receptor (FBrf0222810) pathways.

Source Material

The SCF-SLMB UBIQUITIN LIGASE COMPLEX Gene Group has been compiled using the following publication(s): Wong et al., 2013 and Roberts et al., 2012 .

Key Gene Ontology (GO) terms

Molecular Function

ubiquitin protein ligase activity

Biological Process

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular Component

SCF ubiquitin ligase complex

Enzymatic activity

Enzyme name (EC)

HECT-type E3 ubiquitin transferase (2.3.2.26)

RING-type E3 ubiquitin transferase (2.3.2.27)

RBR-type E3 ubiquitin transferase (2.3.2.31)