FB2026_02 , released June 18, 2026
Gene Group: RHOMBOID PROTEASES
Open Close
General Information
Name
RHOMBOID PROTEASES
Species
D. melanogaster
Symbol
RHOM
FlyBase ID
FBgg0000957
Date last reviewed
2020-06-08
Number of members
6
Description
Description
Rhomboid proteases are intramembrane serine proteases related to rho, that cleave other transmembrane proteins within their transmembrane domains. Rhomboid proteases are best characterized for their role in epidermal growth factor signaling, where they are required for the production the soluble, secreted ligand. They belong to MEROPS family S54. (Adapted from FBrf0235672).
Notes on Group
Source Material
The RHOMBOID PROTEASES Gene Group has been compiled using the following publication(s): Urban et al., 2002, Guichard et al., 2000, Wasserman et al., 2000, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
serine-type endopeptidase activity
Biological Process
epidermal growth factor receptor ligand maturation
Cellular Component
membrane
Enzymatic activity
Enzyme name (EC)
3.4.21.-
Related Gene Groups
Parent group(s)
RHOMBOID-LIKE PROTEINS
SERINE PEPTIDASES
Members (6)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
RHOM
RHOMBOID PROTEASES
Secondary FlyBase ID(s)
References (6)